6-Chloro-5-iodopyridin-2-aMine

Base Information

• Chemical Name: 6-Chloro-5-iodopyridin-2-aMine
• CAS No.: 1221398-11-3
• Molecular Formula: C5H4ClIN2
• Molecular Weight: 254.458
• Hs Code.: 2933399090
• Mol file: 1221398-11-3.mol

Synonyms:6-Chloro-5-iodopyridin-2-aMine;6-Chloro-5-iodo-pyridin-2-ylaMine;1221398-11-3 6-Chloro-5-iodopyridin-2-amine

Chemical Property of 6-Chloro-5-iodopyridin-2-aMine

Chemical Property:

• Boiling Point: 340.4±42.0 °C(Predicted)
• PKA: 1.12±0.10(Predicted)
• PSA: 38.91000
• Density: 2.139±0.06 g/cm3(Predicted)
• LogP: 2.50300
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

6-Chloro-5-iodopyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-5-iodopyridin-2-aMine

There total 2 articles about 6-Chloro-5-iodopyridin-2-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

6-chloropyridin-2-amine (45644-21-1) → 6-chloro-5-iodopyridin-2-ylamine (1221398-11-3)

Guidance literature:

With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2010.01.045

Reference yield:

6-chloropyridin-2-amine (45644-21-1) → 6-chloro-3-iodo-pyridin-2-ylamine (800402-06-6) + 6-chloro-5-iodopyridin-2-ylamine (1221398-11-3) + C5H3ClI2N2

Guidance literature:

With potassium acetate; Iodine monochloride; acetic acid; at 80 ℃; for 4h;

Reference yield:

6-chloro-5-iodopyridin-2-ylamine (1221398-11-3) → 6-amino-2-phenylnicotinonitrile (1621000-07-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene / water; N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; toluene / 1 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; toluene; 2: |Suzuki Coupling;

DOI:10.1016/j.ejmech.2014.07.039

upstream raw materials:

6-chloropyridin-2-amine

Downstream raw materials:

6-amino-2-phenylnicotinonitrile

Refernces

• 1、 -. "FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS". Paragraph 0243. . Retrieved 2018/05/03.
• 2、 -. "Ligand structure includes a new metal complexes". Paragraph 0332; 0333; 0334. . Retrieved 2016/11/24.