(3-(2-(Dimethylamino)ethyl)-2-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-1H-indol-5-yl)-N-methylmethanesulfonamide

Base Information

Chemical Name:(3-(2-(Dimethylamino)ethyl)-2-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-1H-indol-5-yl)-N-methylmethanesulfonamide
CAS No.:545338-89-4
Molecular Formula:C₂₇H₃₇N₅O₂S
Molecular Weight:495.689
Hs Code.:
European Community (EC) Number:839-367-4
UNII:TG89P1S80G
Wikidata:Q27289955
Mol file:545338-89-4.mol

Synonyms:545338-89-4;UNII-TG89P1S80G;Sumatriptan succinate specified impurity A [EP];TG89P1S80G;(3-(2-(Dimethylamino)ethyl)-2-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-1H-indol-5-yl)-N-methylmethanesulfonamide;2-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan;1-[3-[2-(dimethylamino)ethyl]-2-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1H-indol-5-yl]-N-methylmethanesulfonamide;1H-Indole-5-methanesulfonamide, 3-(2-(dimethylamino)ethyl)-2-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-N-methyl-;[3-[2-(diMethylaMino)ethyl]-2-[[3-[2-(diMethylaMino)ethyl]-1H-indol-5-yl]Methyl]-1H-indol-5-yl]-N-MethylMethanesulfonaMide, succinate salt;SCHEMBL946435;Q27289955;SUMATRIPTAN SUCCINATE IMPURITY A [EP IMPURITY]

Suppliers and Price of (3-(2-(Dimethylamino)ethyl)-2-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-1H-indol-5-yl)-N-methylmethanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]Sumatriptan
25mg
$ 1020.00

Sigma-Aldrich
Sumatriptan Succinate Related Compound A
15mg
$ 1490.00

Medical Isotopes, Inc.
2-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]Sumatriptan
25 mg
$ 2440.00

Total 10 raw suppliers

Chemical Property of (3-(2-(Dimethylamino)ethyl)-2-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-1H-indol-5-yl)-N-methylmethanesulfonamide

Chemical Property:

PSA：92.61000
LogP:4.96910
Storage Temp.:Amber Vial, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:3.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:11
Exact Mass:495.26679661
Heavy Atom Count:35
Complexity:770

Purity/Quality:

99%, ^*data from raw suppliers

2-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]Sumatriptan ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNS(=O)(=O)CC1=CC2=C(C=C1)NC(=C2CCN(C)C)CC3=CC4=C(C=C3)NC=C4CCN(C)C
Uses 2-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan Succinate is an impurity of Sumatriptan (S810000), a serotonin 5HT-1-receptor agonist. 2-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan Succinate (Sumatriptan EP Impurity A) is an impurity of Sumatriptan (S810000), a serotonin 5HT-1-receptor agonist.

Technology Process of (3-(2-(Dimethylamino)ethyl)-2-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-1H-indol-5-yl)-N-methylmethanesulfonamide

There total 5 articles about (3-(2-(Dimethylamino)ethyl)-2-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-1H-indol-5-yl)-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 103628-46-2
sumatripan

: 334981-08-7
3-[2-(dimethylamino)ethyl]-5-indolemethanol

: 545338-89-4
[[3-[2-(dimethylamino)ethyl]-2-[[3-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1H-indol-5-yl]-N-methylmethanesulfonamide

Guidance literature:: In propionic acid; for 3h; Heating;

Reference yield:

: 137499-21-9
ethyl 3-[2-(dimethylamino)ethyl]-5-indolecarboxylate

: 545338-89-4
[[3-[2-(dimethylamino)ethyl]-2-[[3-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1H-indol-5-yl]-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

2: 26 percent / propionic acid / 3 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; propionic acid; 2: Friedel-Crafts reaction;

Reference yield:

: 94-09-7
p-aminoethylbenzoate

: 545338-89-4
[[3-[2-(dimethylamino)ethyl]-2-[[3-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1H-indol-5-yl]-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaNO₂*H₂O; aq. HCl / -10 °C

1.2: SnCl₂*2H₂O; aq. HCl

2.1: 34 percent / H₂SO₄ conc. / toluene / 6 h / Heating

3.1: 77 percent / ethanol; H₂O / 6 h / 50 °C

4.1: 95 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

5.1: 26 percent / propionic acid / 3 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; sodium nitrite; In tetrahydrofuran; ethanol; water; propionic acid; toluene; 2.1: Fisher reaction / 5.1: Friedel-Crafts reaction;