Sumatriptan

Base Information Edit

Chemical Name:Sumatriptan
CAS No.:103628-46-2
Molecular Formula:C14H21N3O2S
Molecular Weight:295.406
Hs Code.:2935904000
European Community (EC) Number:600-462-9
UNII:8R78F6L9VO
DSSTox Substance ID:DTXSID4023628
Nikkaji Number:J128.634J
Wikipedia:Sumatriptan
Wikidata:Q416978
NCI Thesaurus Code:C1240
RXCUI:37418
Pharos Ligand ID:A49KX7UHG8K1
Metabolomics Workbench ID:38719
ChEMBL ID:CHEMBL128
Mol file:103628-46-2.mol

Synonyms:3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide;GR 43175;GR-43175;GR43175;Imigran;Succinate, Sumatriptan;Sumatriptan;Sumatriptan Succinate

Suppliers and Price of Sumatriptan

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Sumatriptan
50mg
$ 130.00

TRC
Sumatriptan
250mg
$ 180.00

TRC
Sumatriptan
1g
$ 435.00

Sigma-Aldrich
Sumatriptan
50mg
$ 465.00

Medical Isotopes, Inc.
Sumatriptan
100 mg
$ 290.00

Biosynth Carbosynth
Sumatriptan
50 mg
$ 99.00

Biosynth Carbosynth
Sumatriptan
10 mg
$ 45.00

AvaChem
Sumatriptan
5g
$ 675.00

AvaChem
Sumatriptan
1g
$ 275.00

AvaChem
Sumatriptan
250mg
$ 135.00

Total 119 raw suppliers

Chemical Property of Sumatriptan Edit

Chemical Property:

Appearance/Colour:White to crystalline powder
Vapor Pressure:9.95E-11mmHg at 25°C
Melting Point:169-171 °C
Refractive Index:1.595
Boiling Point:497.7 °C at 760 mmHg
PKA:pKa 9.5 (Uncertain)
Flash Point:254.8 °C
PSA：73.58000
Density:1.243 g/cm³
LogP:2.79290
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)
Water Solubility.:21.4 mg/mL
XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:295.13544809
Heavy Atom Count:20
Complexity:405

Purity/Quality:

99%MIN ^*data from raw suppliers

Sumatriptan ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
Recent ClinicalTrials:A Study on the Effects of Repeat Doses of Intraject? Sumatriptan on Local Site Signs
Recent EU Clinical Trials:Intragastric pressure as a determinant of satiation.
Recent NIPH Clinical Trials:Migraine Study at Emergency Department
Uses Serotonin 5HT1 receptor agonist; treatment of migraine. Sumatriptan is a serotonin 5HT1-receptor agonist.
Therapeutic Function Serotoninergic
Clinical Use 5HT1 receptor agonist: Acute relief of migraine
Drug interactions Potentially hazardous interactions with other drugs Antidepressants: increased risk of CNS toxicity with citalopram, escitalopram, fluoxetine and fluvoxamine - avoid with citalopram; risk of CNS toxicity with MAOIs, moclobemide, SSRIs, sertraline, St John’s Wort - avoid; possibly increased serotonergic effects with duloxetine and venlafaxine. Dapoxetine: possible increased risk of serotonergic effects - avoid for 2 weeks after stopping 5HT1 agonists. Ergot alkaloids: increased risk of vasospasm - avoid.

Technology Process of Sumatriptan

There total 23 articles about Sumatriptan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: benzyl-dimethyl-[2-(5-methylsulfamoylmethyl-1H-indol-3-yl)-ethyl]-ammonium bromide

: 103628-46-2
sumatripan

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 1h;
DOI:10.1002/(SICI)1099-1344(199812)41:12<1127::AID-JLCR158>3.0.CO;2-9