4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one-1-oxide

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Chemical Name:4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one-1-oxide
CAS No.:1418201-60-1
Molecular Formula:C₁₉H₁₆FN₃O₂S
Molecular Weight:369.419
Hs Code.:

Synonyms:4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one-1-oxide

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Chemical Property of 4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one-1-oxide

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Technology Process of 4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one-1-oxide

There total 4 articles about 4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one-1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418201-59-8
4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one

: 1418201-60-1
4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one-1-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

Reference yield:

: 4-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one

: 1418201-60-1
4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one-1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.5 h / 150 °C / Microwave irradiation; Sealed tube

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; 1: |Suzuki Coupling;

Reference yield:

: 1150271-74-1
2-(4-(bromomethyl)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1418201-60-1
4-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one-1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.5 h / 150 °C / Microwave irradiation; Sealed tube

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;