7-Methylpyrazolo[1,5-a]pyriMidin-5(4H)-one

Base Information

• Chemical Name: 7-Methylpyrazolo[1,5-a]pyriMidin-5(4H)-one
• CAS No.: 29269-60-1
• Molecular Formula: C7H7N3O
• Molecular Weight: 149.14998
• Hs Code.: 2933990090
• Mol file: 29269-60-1.mol

Synonyms:7-Methylpyrazolo[1,5-a]pyriMidin-5(4H)-one

Chemical Property of 7-Methylpyrazolo[1,5-a]pyriMidin-5(4H)-one

Chemical Property:

• PSA: 50.16000
• LogP: 0.33100
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

7-Methylpyrazolo[1,5-a]pyrimidin-5(4H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Methylpyrazolo[1,5-a]pyriMidin-5(4H)-one

There total 2 articles about 7-Methylpyrazolo[1,5-a]pyriMidin-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3-aminopyrazole (1820-80-0,916420-28-5) + Ethyl 2-butynoate (4341-76-8) → 7-methylpyrazolo[1,5-a]pyrimidin-5(4H)-one (29269-60-1)

Guidance literature:

3-aminopyrazole; Ethyl 2-butynoate; In 1,4-dioxane; at 110 ℃; for 2h; Microwave irradiation; Inert atmosphere;

With sodium methylate; In 1,4-dioxane; at 20 ℃; for 12h; Microwave irradiation; Inert atmosphere;

DOI:10.1002/ejoc.201701024

Reference yield:

→ 7-methylpyrazolo[1,5-a]pyrimidin-5(4H)-one (29269-60-1)

Guidance literature:

3(5)-Amino-pyrazol 3, Tetrolsaeure-methylester 4a;

Reference yield: 71.0%

4-methoxyphenylboronic acid (5720-07-0) + 7-methylpyrazolo[1,5-a]pyrimidin-5(4H)-one (29269-60-1) → 5-(4-methoxyphenyl)-7-methylpyrazolo[1,5-a]pyrimidine

Guidance literature:

7-methylpyrazolo[1,5-a]pyrimidin-5(4H)-one; With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; at 20 ℃; for 2h; Inert atmosphere;

4-methoxyphenylboronic acid; With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201701024

upstream raw materials:

3-aminopyrazole

Ethyl 2-butynoate

Refernces