Boronic acid, (2,6-diethoxyphenyl)- (9CI)

Base Information

• Chemical Name: Boronic acid, (2,6-diethoxyphenyl)- (9CI)
• CAS No.: 327618-51-9
• Molecular Formula: C10H15BO4
• Molecular Weight: 210.0347
• Mol file: 327618-51-9.mol

Synonyms:Boronic acid, (2,6-diethoxyphenyl)- (9CI)

Chemical Property of Boronic acid, (2,6-diethoxyphenyl)- (9CI)

Chemical Property:

• Boiling Point: 390.3±52.0 °C(Predicted)
• PKA: 8.61±0.58(Predicted)
• PSA: 58.92000
• Density: 1.13±0.1 g/cm3(Predicted)
• LogP: 0.16380

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boronic acid, (2,6-diethoxyphenyl)- (9CI)

There total 3 articles about Boronic acid, (2,6-diethoxyphenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.7%

2,6-diethoxyphenylboronic acid → 2,6-diethoxyphenylboronic acid (327618-51-9)

Guidance literature:

With sulfuric acid; In water; at -20 ℃;

DOI:10.1039/c2ce25657f

Reference yield:

Trimethyl borate (121-43-7,63156-11-6) + 2,4-diethoxybenzene (2049-73-2) → 2,6-diethoxyphenylboronic acid (327618-51-9)

Guidance literature:

With phenyllithium; In cyclohexane;

Reference yield:

recorcinol (108-46-3) → 2,6-diethoxyphenylboronic acid (327618-51-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide; tetrabutylammomium bromide / water / 5 h / Reflux

2.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / diethyl ether / 1 h / -20 - -10 °C / Inert atmosphere

2.2: -65 - 20 °C

3.1: sulfuric acid / water / -20 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; tetrabutylammomium bromide; sodium hydroxide; In diethyl ether; water;

DOI:10.1039/c2ce25657f

upstream raw materials:

Trimethyl borate

2,4-diethoxybenzene

recorcinol

Refernces

• 1、 -. "Heterocycle amides as cell adhesion inhibitors". . . Retrieved 2008/06/13.