2049-73-2

Usage

Chemical Properties

clear light yellow liquid

InChI:InChI=1/C10H14O2/c1-3-11-9-6-5-7-10(8-9)12-4-2/h5-8H,3-4H2,1-2H3

Upstream product

• 6025-45-2 disodium resorcinolate 
• 75-03-6 ethyl iodide 
• 64-17-5 ethanol 
• 141-52-6 sodium ethanolate 
• 108-46-3 recorcinol 
• 54494-87-0 resorcinol; sodium-compound 
• 80-40-0 ethyl ester of p-toluenesulfonic acid 
• 74-96-4 ethyl bromide 
• 563-17-7 potassium ethyl sulfate 
• 5323-87-5 3-Ethoxycyclohex-2-en-1-one 
• 1801-77-0 oxovanadium(V) ethoxydichloride 
• 504-02-9 1,3-cylohexanedione 
• 595-31-3 (+)-(1S,3R)-1,2,2-trimethylcyclopentane-1,3-dicarboxylic anhydride 
• 7732-18-5 water 

Downstream Products

• 39560-29-7 4-(2,4-diethoxy-phenyl)-4-oxo-butyric acid 
• 22924-16-9 2,4-diethoxy-benzaldehyde 
• 64635-54-7 3-ethoxy-4-nitrophenol 
• 857629-22-2 5-ethoxy-2-nitro-phenol 
• 90841-12-6 2,4-diethoxy-1,3,5-trinitro-benzene 
• 140404-78-0 3-ethoxy-4-nitroso-phenol 
• 121550-98-9 1,5-diethoxy-2,4-dibromo-benzene 
• 155048-08-1 2',4'-diethoxy-trans-chalcone 
• 22924-18-1 2′,4′-diethoxyacetophenone 
• 2161-85-5 1-(5-acetyl-2,4-dihydroxyphenyl)-1-ethanone 
• 90109-28-7 1,3-Diethoxy-2-ethylsulfanyl-benzene 
• 90109-23-2 2,6-diethoxythioanisole 
• 115167-61-8 2-(2,4-Diethoxy-phenyl)-3,3,3-trifluoro-2-hydroxy-propionic acid methyl ester 
• 90420-30-7 (2,6-diethoxyphenyl)-methyl-phosphinigsaurediethylamid 

Relevant academic research and scientific papers

Towards a monomeric structure of phenylboronic acid: The influence of ortho-alkoxy substituents on the crystal structure

The structures of three ortho-alkoxyphenylboronic acids (2-methoxy-, 2-ethoxy-, 2-isobutoxy-), and three diortho-alkoxyphenylboronic acids (2,6-dimethoxy-, 2,6-diethoxy- and 2-isobutoxy-6-methoxy) were determined by single crystal X-ray diffraction. The study was undertaken with the intention of designing a novel boronic acid having a monomeric structure, which to date has been an unavailable building block for crystal engineering. This motif can be enhanced by involving two hydroxyl groups at the boron atom in intramolecular hydrogen bonds. Although monosubstituted systems form typical dimers in the crystal lattice, disubstituted species reveal a much bigger variety of possible interactions. Among the analyzed compounds, 2,6-dimethoxyphenylboronic acid and 2,6-diethoxyphenylboronic acid crystallize in two polymorphic forms each. The unprecedented packing with monomers as the dominant structural motif has been found in the crystal structure of 2-isobutoxy-6-methoxyphenylboronic acid and one of the polymorphs of both 2,6-dimethoxyphenylboronic acid and 2,6-diethoxyphenylboronic acid. This description of the molecular packing is also supported by the analysis of fingerprint 2-D plots based on the Hirshfeld surfaces. The variety of possible types of interactions either within a single moiety or between moieties in dimers were additionally analyzed on the basis of the interaction energies, which have been estimated by ab initio calculations at the MP2/6-31+G* and B3LYP/6-311+G** level of theory.

Iodine-catalyzed tandem oxidative aromatization for the synthesis of meta-substituted alkoxybenzenes

A rapid method for the synthesis of meta-substituted alkoxybenzenes is achieved by oxidation of cyclohexenones. This one-pot transformation is catalyzed by molecular iodine with DDQ as an oxidant in the presence of alcohols. Diverse cyclohexenones with aryl or alkyl substitutes are well tolerated to the mild oxidative conditions affording desired products in up to 92% yield. These oxidizing processes were applicable to the efficient synthesis of useful meta-substituted phenolic products which are difficult to obtain by traditional electrophilic substitutions.

skin whitening agent

The present invention relates to a composition for skin whitening containing 1,3-diethoxy benzene having excellent skin whitening activity as an active component, which has excellent skin whitening effect and does not have side effect to have excellent safety. Provided in the present invention is a cosmetic composition containing a compound represented by chemical formula 1 as an active component and having excellent melanin generation controlling effect. The cosmetic composition of the present invention has excellent skin whitening effect and almost does not have skin stimulation on a human body to have excellent safety of products to be useful as a cosmetic composition for skin whitening.

Composition FOR PREVENTING ALOPECIA AND ACTIVATING HAIR GROWTH

The present invention provides a hair growth promoter comprising as an active ingredient, a compound having a chemical structure of general formula (1) or a pharmacologically acceptable salt thereof. In the general formula (1): R_1 is a saturated or unsaturated straight chain or branched C1-C10 alkyl group or hydroxy alkyl group; R_2 is hydrogen or a saturated or unsaturated straight chain or branched C1-C10 alkoxy or hydroxy alkoxy; X is hydrogen, hydroxy, or a saturated or unsaturated straight chain or branched C1-C10 alkyl group, alkoxy or hydroxyl alkoxy; R_3 and R_4 are each independently selected from R_5, hydrogen, aldehyde, and a saturated or unsaturated straight chain or branched alkyl, alkoxy, or hydroxy alkoxy; R_5 has a structure of # AAA #; R_6 is selected from hydrogen, and a saturated or unsaturated straight chain or branched C1-C10 alkyl, alkoxy, or hydroxy alkoxy; and one of R_3 and R_4 is hydrogen.COPYRIGHT KIPO 2017

High-Loading Crystals of Tetraaryladamantanes and the Uptake and Release of Aromatic Hydrocarbons from the Gas Phase

Recently, a tetraphenyladamantane octamethylether was shown to encapsulate a wide range of small molecules in its crystals. Uptake and release from the liquid phase were demonstrated, and crystalline inclusion complexes were prepared that act as formulation for obnoxious reagents. However, fewer than two equivalents of guest molecules were found within the crystal structures. Here we report the synthesis of 1,3,5,7-tetrakis(2,4-diethoxyphenyl)adamantane (TEO) and twelve X-ray crystal structures that contain up to 3.5 equivalents of guest molecules. After crystallization and drying, TEO gives a material that absorbs 30 wt % of p-xylene reversibly through the gas phase, and releases it again at 55 °C, suggesting that it may be used for the capture and release of aromatic hydrocarbons.

Gold-Catalyzed Proto- and Deuterodeboronation

A mild gold-catalyzed protodeboronation reaction, which does not require acid or base additives and can be carried out in "green" solvents, is described. As a result, the reaction is very functional-group-tolerant, even to acid- and base-sensitive functional groups, and should allow for the boronic acid group to be used as an effective traceless directing or blocking group. The reaction has also been extended to deuterodeboronations for regiospecific ipso-deuterations of aryls and heteroaryls from the corresponding organoboronic acid. Based on density functional theory calculations, a mechanism is proposed that involves nucleophilic attack of water at boron followed by rate-limiting B-C bond cleavage and facile protonolysis of a Au-σ-phenyl intermediate.

Synthesis of 2,6-disubstituted benzylamine derivatives as reversible selective inhibitors of copper amine oxidases

In order to obtain substrate-like inhibitors of copper amine oxidases (CAOs), a class of enzymes involved in important cellular processes as well as in crosslinking of elastin and collagen and removal of biogenic primary amines, we synthesized a set of benzylamine derivatives properly substituted at positions 2 and 6 and studied their biological activity towards some members of CAOs. With benzylamines 6, 7, 8 containing linear alkoxy groups we obtained reversible inhibitors of benzylamine oxidase (BAO), very active and selective toward diamine oxidase (DAO), lysyl oxidase (LO) and monoamine oxidase B (MAO B) characterized by a certain toxicity consequent to the crossing of the brain barrier. Poorly toxic, up to very active, reversible inhibitors of BAO, very selective toward DAO, LO and MAO B, were obtained with benzylamines 10, 11, 12 containing hydrophilic ω-hydroxyalkoxy groups. With benzylamines 13, 14, 15, containing linear alkyl groups endowed with steric, but not conjugative effects for the absence of properly positioned oxygen atoms, we synthesized moderately active inhibitors of BAO reversible and selective toward DAO, LO and MAO B. The cross examination of the entire biological data brought us to the conclusion that the bioactive synthesized compounds most likely exert their physiological role of reversible inhibitors in consequence of the formation of a plurality of hydrogen bonds or hydrophobic non-covalent interactions with proper sites in the protein. Accordingly, the reported inhibitors may be considered as a set of research tools for general biological studies and the formation of enzyme complexes useful for X-ray structure determinations aimed at the design of more sophisticated inhibitors to always better modulate the protein activity without important side effects.

Rh(I)-catalyzed decarboxylative transformations of arenecarboxylic acids: Ligand- and reagent-controlled selectivity toward hydrodecarboxylation or heck-mizoroki products

(Chemical Equetion Presentation) A Rh(I)-based catalyst system has been developed to promote three types of decarboxylative transformations of arenecarboxylic acids: (1) hydrodecarboxylation, (2) Heck-Mizoroki olefination, and (3) conjugate addition. Scopes of reactions (1) and (2) were studied, and the ligand and reagent dependence of selectivity was explored.

METHODS AND COMPOSITIONS FOR CONTROL OF GYPSY MOTHS, Lymanria dispar

The invention provides in part dialkoxybenzene and eugenol compounds for controlling infestation by a Lymantria dispar, and methods thereof. The compounds include a compound of Formula I: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; R2 may be at positions 2, 3 or 4 and may be H, methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; and R3 may be optionally present at positions 2, 3 and 4, and is allyl; with the provisos that when R2 is at position 2, R3 if present is at position 3, or when R2 is at to position 3, R3 if present is at positions 2 or 4, or when R2 is at position 4, R3 if present is at position 2; or of Formula II: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; or mixtures thereof.

METHODS AND COMPOSITIONS FOR CONTROL OF CABBAGE LOOPER, Trichoplusia ni

The invention provides in part dialkoxybenzene compounds for controlling infestation by a Trichoplusia ni, and methods thereof. The compounds include a compound of Formula I: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl(3-methylbutyl) or allyl; R2 may be at positions 2, 3 or 4 and may be H, methyl, ethyl, propyl, n-butyl, isopentyl(3-methylbutyl) or allyl; and R3 may be optionally present at positions 2, 3 and 4, and is allyl; except that when R2 is at position 2, R3 if present is at position 3, and when R2 is at position 3, R3 if present is at positions 2 or 4, and when R2 is at position 4, R3 if present is at position 2, and when R2 is at position 4 and R3, if present, has reacted with an OH group at position 1 in a Markovnikov sense, then R3 becomes R4, a dihydrofuran.