2049-73-2Relevant articles and documents
Towards a monomeric structure of phenylboronic acid: The influence of ortho-alkoxy substituents on the crystal structure
Cyranski, Michal K.,Klimentowska, Paulina,Stepien, Dorota K.,Rydzewska, Agata,Serwatowski, Janusz,Sporzynski, Andrzej
, p. 6282 - 6294,13 (2012)
The structures of three ortho-alkoxyphenylboronic acids (2-methoxy-, 2-ethoxy-, 2-isobutoxy-), and three diortho-alkoxyphenylboronic acids (2,6-dimethoxy-, 2,6-diethoxy- and 2-isobutoxy-6-methoxy) were determined by single crystal X-ray diffraction. The study was undertaken with the intention of designing a novel boronic acid having a monomeric structure, which to date has been an unavailable building block for crystal engineering. This motif can be enhanced by involving two hydroxyl groups at the boron atom in intramolecular hydrogen bonds. Although monosubstituted systems form typical dimers in the crystal lattice, disubstituted species reveal a much bigger variety of possible interactions. Among the analyzed compounds, 2,6-dimethoxyphenylboronic acid and 2,6-diethoxyphenylboronic acid crystallize in two polymorphic forms each. The unprecedented packing with monomers as the dominant structural motif has been found in the crystal structure of 2-isobutoxy-6-methoxyphenylboronic acid and one of the polymorphs of both 2,6-dimethoxyphenylboronic acid and 2,6-diethoxyphenylboronic acid. This description of the molecular packing is also supported by the analysis of fingerprint 2-D plots based on the Hirshfeld surfaces. The variety of possible types of interactions either within a single moiety or between moieties in dimers were additionally analyzed on the basis of the interaction energies, which have been estimated by ab initio calculations at the MP2/6-31+G* and B3LYP/6-311+G** level of theory.
skin whitening agent
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Paragraph 0022-0025, (2020/11/20)
The present invention relates to a composition for skin whitening containing 1,3-diethoxy benzene having excellent skin whitening activity as an active component, which has excellent skin whitening effect and does not have side effect to have excellent safety. Provided in the present invention is a cosmetic composition containing a compound represented by chemical formula 1 as an active component and having excellent melanin generation controlling effect. The cosmetic composition of the present invention has excellent skin whitening effect and almost does not have skin stimulation on a human body to have excellent safety of products to be useful as a cosmetic composition for skin whitening.
Composition FOR PREVENTING ALOPECIA AND ACTIVATING HAIR GROWTH
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Paragraph 0116; 0176; 0177, (2018/02/16)
The present invention provides a hair growth promoter comprising as an active ingredient, a compound having a chemical structure of general formula (1) or a pharmacologically acceptable salt thereof. In the general formula (1): R_1 is a saturated or unsaturated straight chain or branched C1-C10 alkyl group or hydroxy alkyl group; R_2 is hydrogen or a saturated or unsaturated straight chain or branched C1-C10 alkoxy or hydroxy alkoxy; X is hydrogen, hydroxy, or a saturated or unsaturated straight chain or branched C1-C10 alkyl group, alkoxy or hydroxyl alkoxy; R_3 and R_4 are each independently selected from R_5, hydrogen, aldehyde, and a saturated or unsaturated straight chain or branched alkyl, alkoxy, or hydroxy alkoxy; R_5 has a structure of # AAA #; R_6 is selected from hydrogen, and a saturated or unsaturated straight chain or branched C1-C10 alkyl, alkoxy, or hydroxy alkoxy; and one of R_3 and R_4 is hydrogen.COPYRIGHT KIPO 2017
