t-butyl 4-(1-methylpiperidine-4-yloxy)-3-(trifluoromethyl)phenylcarbamate

Base Information

Chemical Name:t-butyl 4-(1-methylpiperidine-4-yloxy)-3-(trifluoromethyl)phenylcarbamate
CAS No.:1318242-90-8
Molecular Formula:C₁₈H₂₅F₃N₂O₃
Molecular Weight:374.403
Hs Code.:

Synonyms:t-butyl 4-(1-methylpiperidine-4-yloxy)-3-(trifluoromethyl)phenylcarbamate

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Chemical Property of t-butyl 4-(1-methylpiperidine-4-yloxy)-3-(trifluoromethyl)phenylcarbamate

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Technology Process of t-butyl 4-(1-methylpiperidine-4-yloxy)-3-(trifluoromethyl)phenylcarbamate

There total 4 articles about t-butyl 4-(1-methylpiperidine-4-yloxy)-3-(trifluoromethyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 4-((1-methylpiperidin-4-yl)oxy)-3-(trifluoromethyl)benzoic acid

: 75-65-0
tert-butyl alcohol

: 1318242-90-8
t-butyl 4-(1-methylpiperidine-4-yloxy)-3-(trifluoromethyl)phenylcarbamate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; at 90 ℃; for 23h;

Reference yield:

: 220239-68-9
4-hydroxy-3-(trifluoromethyl)benzoic acid

: 1318242-90-8
t-butyl 4-(1-methylpiperidine-4-yloxy)-3-(trifluoromethyl)phenylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 48 h / 90 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 0 - 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 22 h / 90 °C

3.2: 20 °C / pH 4

4.1: triethylamine; diphenyl phosphoryl azide / 23 h / 90 °C

With di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; water; triethylamine; triphenylphosphine; sodium hydroxide; hydrogenchloride; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1318242-89-5
methyl 4-((1-methylpiperidin-4-yl)oxy)-3-(trifluoromethyl)benzoate

: 1318242-90-8
t-butyl 4-(1-methylpiperidine-4-yloxy)-3-(trifluoromethyl)phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / tetrahydrofuran; methanol / 22 h / 90 °C

1.2: 20 °C / pH 4

2.1: triethylamine; diphenyl phosphoryl azide / 23 h / 90 °C

With diphenyl phosphoryl azide; water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol;