220239-68-9

Basic information

• Product Name: 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOIC ACID
• Synonyms: 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOIC ACID;RARECHEM AL BE 1191;4-Carboxy-2-(trifluoromethyl)phenol, 5-Carboxy-2-hydroxybenzotrifluoride
• CAS NO: 220239-68-9
• Molecular Formula: C₈H₅F₃O₃
• Molecular Weight: 206.12
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 220239-68-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 144-147°C
• Boiling Point: 301.7 °C at 760 mmHg
• Flash Point: 136.2 °C
• Appearance: /
• Density: 1.539 g/cm³
• Vapor Pressure: 0.00046mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOIC ACID(220239-68-9)
• EPA Substance Registry System: 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOIC ACID(220239-68-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 220239-68-9(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-3-(trifluoromethyl)benzoic acid is a chemical compound with the molecular formula C8H5F3O3. It is a derivative of benzoic acid and contains a hydroxy group and a trifluoromethyl group attached to the benzene ring. 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOIC ACID is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has been found to have potential applications in the field of medicinal chemistry due to its unique structure and functional groups. Additionally, 4-Hydroxy-3-(trifluoromethyl)benzoic acid may have potential uses in the development of new materials and as a building block for the synthesis of more complex organic molecules.

InChI:InChI=1/C8H5F3O3/c9-8(10,11)5-3-4(7(13)14)1-2-6(5)12/h1-3,12H,(H,13,14)

Upstream product

• 213598-09-5 4-methoxy-3-(trifluoromethyl)benzoic acid 

Downstream Products

• 115933-50-1 methyl 4-hydroxy-3-(trifluoromethyl)benzoate 
• 1198153-84-2 (4-hydroxy-3-trifluoromethyl-phenyl)-(7-methyl-2,3-dihydro-pyrido[2,3-b][1,4]oxazin-1-yl)-methanone 
• 1215118-42-5 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)aceticacid 
• 1215118-92-5 (4-isopropoxy-3-(trifluoromethyl)phenyl)methanol 
• 1215118-94-7 4-(chloromethyl)-1-isopropoxy-2-(trifluoromethyl)benzene 
• 1215118-95-8 tert-butyl 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate 
• 1215118-50-5 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid 
• 1215118-97-0 tert-butyl 2-(9-iodo-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate 
• 1215118-98-1 tert-butyl 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate 
• 1215118-59-4 2-(2-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetic acid 
• 1215119-10-0 Ethyl 2-(2-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate 
• 1215119-52-0 (S)-2-(2-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetic acid 
• 1215119-51-9 (R)-2-(2-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetic acid 
• 956904-10-2 4-trifluoromethanesulfonyloxy-3-trifluoromethylbenzoic acid methyl ester 

Relevant articles and documents

BENZAMIDE DERIVATIVE

The present invention relates to benzamide derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.

CGRP ANTAGONISTS, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE AS MEDICAMENTS

The invention relates to CGRP antagonists of general formula (I) in which: R1, R2, R3, R4 and X are defined as in Claim 1, to their tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts as well as the hydrates of the salts, in particular, their physiologically compatible salts with inorganic or organic acids and bases, and those compounds of general formula (I) in which one or more hydrogen atoms are replaced by deuterium. The invention also relates to medicaments containing these compounds, the use thereof, and to methods for producing them.

2-FURANCARBOXYLIC ACID HYDRAZIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

The present invention provides 2-furancarboxylic acid hydrazide compounds represented by General Formula(I) below, and prodrugs, physiologically acceptable salts, hydrates, solvates thereof, methods for producing them and pharmaceutical compositions containing them: wherein A is a group represented by Formula (a) or the like: (wherein either R4 or R5 represents cyano, nitro or the like, and the other represents a hydrogen atom or the like); either R1 or R2 represents a group: -D-(X)m-R6 or the like, and the other represents a group: -E-(Y)n-R7, hydrogen atom, aryl or the like; R3 is a hydrogen atom or the like; D and E independently represent aryl; X and Y independently represent 0 or the like; R6 and R7 independently represent alkyl, aryl, arylalkyl or the like; and m and n are independently 0 or 1, provided that the aryl is optionally substituted. Such compounds exhibit a potent antagonistic activity on glucagon receptor and are of use as preventive and/or therapeutic agents for symptoms and diseases in which glucagon is involved.