(R)-2-Methyl-1-phenylpropan-1-amine hydrochloride

Base Information

• Chemical Name: (R)-2-Methyl-1-phenylpropan-1-amine hydrochloride
• CAS No.: 51600-25-0
• Molecular Formula: C10H16ClN
• Molecular Weight: 185.697
• European Community (EC) Number: 800-376-3
• DSSTox Substance ID: DTXSID30704145
• Mol file: 51600-25-0.mol

Synonyms:51600-25-0;(R)-2-Methyl-1-phenylpropan-1-amine hydrochloride;(R)-2-METHYL-1-PHENYLPROPAN-1-AMINE HCl;(1R)-2-methyl-1-phenylpropan-1-amine;hydrochloride;(1R)-2-methyl-1-phenylpropan-1-amine hydrochloride;(R)-2-Methyl-1-phenylpropan-1-aminehydrochloride;DTXSID30704145;MFCD12068520;AKOS015923071;AKOS016002817;GS-7217;CS-0154339;(R)-2-Methyl-1-phenylpropylamine hydrochloride;A871223;(1R)-2-Methyl-1-phenyl-1-propanamine hydrochloride;[(1R)-2-methyl-1-phenylpropyl]amine hydrochloride;(1R)-2-Methyl-1-phenyl-1-propanamine hydrochloride, AldrichCPR;(1R)-2-Methyl-1-phenylpropan-1-amine--hydrogen chloride (1/1);(?R)-?-(1-Methylethyl)benzenemethanamine Hydrochloride (1:1);Benzenemethanamine, ?-(1-methylethyl)-, hydrochloride, (R)-;Benzenemethanamine, ?-(1-methylethyl)-, hydrochloride, (?R)- (9CI)

Chemical Property of (R)-2-Methyl-1-phenylpropan-1-amine hydrochloride

Chemical Property:

• PSA: 26.02000
• LogP: 3.84470
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 185.0971272
• Heavy Atom Count: 12
• Complexity: 103

Purity/Quality:

98% ^*data from raw suppliers

(R)-2-Methyl-1-phenylpropan-1-amineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C(C1=CC=CC=C1)N.Cl
• Isomeric SMILES: CC(C)[C@H](C1=CC=CC=C1)N.Cl

Technology Process of (R)-2-Methyl-1-phenylpropan-1-amine hydrochloride

There total 7 articles about (R)-2-Methyl-1-phenylpropan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(RS,R)-N-(2-methyl-1-phenylpropyl)-2-methylpropane-2-sulfinamide (196929-93-8) → (R)-2-methyl-1-phenylpropylamine hydrochloride (51600-25-0,68906-27-4)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 1.5h;

DOI:10.1021/ol400439g

Reference yield: 80.1%

bromobenzene (108-86-1,52753-63-6) + Ss-2-methyl-propane-2-sulfinic acid [2-methylpropylidene]amide (1175603-96-9) → (R)-2-methyl-1-phenylpropylamine hydrochloride (51600-25-0,68906-27-4)

Guidance literature:

bromobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -50 - -40 ℃;

S_s-2-methyl-propane-2-sulfinic acid [2-methylpropylidene]amide; In tetrahydrofuran; hexane; at -50 - -40 ℃;

With hydrogenchloride; In isopropyl alcohol; for 1h; enantioselective reaction;

DOI:10.1080/00397911.2014.909487

Reference yield: 76.0%

phenylmagnesium bromide + (R,E)-2-methyl-N-(2-methylpropylidene)propane-2-sulfinamide (220315-19-5) → (R)-2-methyl-1-phenylpropylamine hydrochloride (51600-25-0,68906-27-4) + (S)-2-methyl-1-phenylpropan-1-amine hydrochloride (68906-27-4)

Guidance literature:

phenylmagnesium bromide; (R,E)-2-methyl-N-(2-methylpropylidene)propane-2-sulfinamide; In diethyl ether; dichloromethane; at -48 ℃;

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 0.5h; Solvolysis;

DOI:10.1016/S0040-4020(99)00451-2

upstream raw materials:

benzhydrylidene-benzyl-amine

isopropyl bromide

(R_S,R)-N-(2-methyl-1-phenylpropyl)-2-methylpropane-2-sulfinamide

(R,E)-2-methyl-N-(2-methylpropylidene)propane-2-sulfinamide

Downstream raw materials:

(R)-5-bromo-N-(2-methyl-1-phenylpropyl)-2-nitroaniline

Refernces

• 1、 Fernandez-Salas, Jose A.,Maestro, M. Carmen,Rodriguez-Fernandez, M. Mercedes,Garcia-Ruano, Jose L.,Alonso, Ines. "Intermolecular alkyl radical additions to enantiopure N-tert-butanesulfinyl aldimines". supporting information. p. 1658 - 1661. Retrieved 2013/06/26.
• 2、 Liu,Cogan,Ellman. "Catalytic asymmetric synthesis of tert-butanesulfinamide. Application to the asymmetric synthesis of amines". . p. 9913 - 9914. Retrieved 2007/10/03.