(4-Boc-Amino-piperidin-1-yl)acetic acid ethylester

Base Information

• Chemical Name: (4-Boc-Amino-piperidin-1-yl)acetic acid ethylester
• CAS No.: 203662-91-3
• Molecular Formula: C₁₄H₂₆N₂O₄
• Molecular Weight: 286.371
• Hs Code.: 2933399090
• Mol file: 203662-91-3.mol

Synonyms:(4-Boc-Amino-piperidin-1-yl)acetic acid ethylester

Chemical Property of (4-Boc-Amino-piperidin-1-yl)acetic acid ethylester

Chemical Property:

• Vapor Pressure: 3.83E-06mmHg at 25°C
• Boiling Point: 385.4°C at 760 mmHg
• Flash Point: 186.9°C
• PSA: 67.87000
• Density: 1.09g/cm³
• LogP: 1.86740

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(4-{[(tert-Butoxy)carbonyl]amino}piperidin-1-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-Boc-Amino-piperidin-1-yl)acetic acid ethylester

There total 1 articles about (4-Boc-Amino-piperidin-1-yl)acetic acid ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl bromoacetate (105-36-2) + (piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) → 4-[(tert-butyloxycarbonyl)amino]-1-[(ethoxycarbonyl)methyl]piperidine (203662-91-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; Heating;

DOI:10.1021/jm990468g

Reference yield:

4-[(tert-butyloxycarbonyl)amino]-1-[(ethoxycarbonyl)methyl]piperidine (203662-91-3) → 4-[(phenylsulfonyl)amino]-N-[cis-1,2,3,4-tetrahydro-6-fluoro-1-(3-pyridinylmethyl)-2-naphthalenyl]-1-piperidineacetamide bis-trifluoroacetate

Guidance literature:

Multi-step reaction with 4 steps

1: aq. sodium hydroxide / methanol

2: HBTU; DIEA / dimethylformamide / 20 °C

3: aq. TFA / CH₂Cl₂; H₂O / 20 °C

4: DIEA / acetonitrile / 20 °C

With sodium hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 1: Hydrolysis / 2: Acylation / 3: Hydrolysis / 4: Sulfonylation;

DOI:10.1021/jm990468g

Reference yield:

4-[(tert-butyloxycarbonyl)amino]-1-[(ethoxycarbonyl)methyl]piperidine (203662-91-3) → piperidin-N-acetic acid 4-yl-carbamic acid tert-butyl ester (299203-94-4)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1021/jm990468g

upstream raw materials:

ethyl bromoacetate

(piperidin-4-yl)carbamic acid tert-butyl ester

Downstream raw materials:

piperidin-N-acetic acid 4-yl-carbamic acid tert-butyl ester

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