1-Trimethylacetylpyrrole

Base Information

• Chemical Name: 1-Trimethylacetylpyrrole
• CAS No.: 411208-03-2
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• Hs Code.: 2933990090
• Mol file: 411208-03-2.mol

Synonyms:1-Trimethylacetylpyrrole;2,2-Dimethyl-1-(1H-pyrrol-1-yl)propan-1-one

Chemical Property of 1-Trimethylacetylpyrrole

Chemical Property:

• PSA: 22.00000
• LogP: 2.17440

Purity/Quality:

97% ^*data from raw suppliers

2,2-Dimethyl-1-(1H-pyrrol-1-yl)propan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Trimethylacetylpyrrole

There total 1 articles about 1-Trimethylacetylpyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

pyrrole (109-97-7,30604-81-0) + pivaloyl chloride (3282-30-2) → 2,2-dimethyl-1-(1H-pyrrol-1-yl)propan-1-one (411208-03-2)

Guidance literature:

With triethylamine; dmap; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ja0745862

Reference yield: 57.0%

Methyl phenyldiazoacetate (22979-35-7) + 2,2-dimethyl-1-(1H-pyrrol-1-yl)propan-1-one (411208-03-2) → methyl 6-phenyl-2-pivaloyl-2-azabicyclo[3.1.0]hex-3-ene-6-carboxylate

Guidance literature:

With C₃₃H₂₈NNiO₃P; In toluene; at 0 - 100 ℃; for 24.3333h; diastereoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.0c02138

Reference yield: 53.0%

2,2-dimethyl-1-(1H-pyrrol-1-yl)propan-1-one (411208-03-2) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 2,5-diphenyl-N-pivaloylpyrrole + biphenyl (92-52-4,1594-86-1)

Guidance literature:

With silver(I) acetate; Trimethylacetic acid; Pd(OPiv)2; at 100 ℃;

DOI:10.1021/ja0745862

upstream raw materials:

pyrrole

pivaloyl chloride

Downstream raw materials:

biphenyl