Fluorotrimethylsilylketene Ethyl Trimethylsilyl Acetal (mixture of isomers)

Base Information

• Chemical Name: Fluorotrimethylsilylketene Ethyl Trimethylsilyl Acetal (mixture of isomers)
• CAS No.: 1068142-02-8
• Molecular Formula: C10H23FO2Si2
• Molecular Weight: 250.461
• Mol file: 1068142-02-8.mol

Synonyms:Fluorotrimethylsilylketene Ethyl Trimethylsilyl Acetal (mixture of isomers);FLUOROTRIMETHYLSILYLKETENE ETHYL TRIMETHYLSILYL ACETAL;[[1-Ethoxy-2-fluoro-2-(trimethylsilyl)ethenyl]oxy]trimethylsilane

Chemical Property of Fluorotrimethylsilylketene Ethyl Trimethylsilyl Acetal (mixture of isomers)

Chemical Property:

• Refractive Index: 1.42
• PSA: 18.46000
• LogP: 3.89040
• Storage Temp.: 0-10°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fluorotrimethylsilylketene Ethyl Trimethylsilyl Acetal (mixture of isomers) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Fluorotrimethylsilylketene Ethyl Trimethylsilyl Acetal (mixture of isomers)

There total 1 articles about Fluorotrimethylsilylketene Ethyl Trimethylsilyl Acetal (mixture of isomers) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

chloro-trimethyl-silane (75-77-4) + ethyl 2-fluoroacetate (459-72-3) → fluoro(trimethylsilyl)ketene ethyl trimethylsilyl acetal (1068142-02-8)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1246/cl.2008.890

Reference yield: 88.0%

fluoro(trimethylsilyl)ketene ethyl trimethylsilyl acetal (1068142-02-8) + 4-chlorobenzaldehyde (104-88-1) → ethyl (Z)-3-(4-chlorophenyl)-2-fluoroacrylate

Guidance literature:

With 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene; In acetonitrile; at 0 - 20 ℃; stereoselective reaction;

DOI:10.1016/j.tet.2015.11.044

Reference yield: 85.0%

fluoro(trimethylsilyl)ketene ethyl trimethylsilyl acetal (1068142-02-8) + 3-methoxy-benzaldehyde (591-31-1) → ethyl (Z)-2-fluoro-3-(3-methoxyphenyl)acrylate

Guidance literature:

With 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene; In acetonitrile; at 0 - 20 ℃; stereoselective reaction;

DOI:10.1016/j.tet.2015.11.044

upstream raw materials:

chloro-trimethyl-silane

ethyl 2-fluoroacetate

Downstream raw materials:

ethyl (2Z)-3-fluoro-3-phenylprop-2-enoate

Refernces