4-Bromo-2-fluoro-3-methoxybenzonitrile

Base Information

• Chemical Name: 4-Bromo-2-fluoro-3-methoxybenzonitrile
• CAS No.: 1426073-33-7
• Molecular Weight: 230.03
• Hs Code.: 2926907090
• Mol file: 1426073-33-7.mol

Synonyms:4-Bromo-2-fluoro-3-methoxybenzonitrile

Chemical Property of 4-Bromo-2-fluoro-3-methoxybenzonitrile

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2-fluoro-3-methoxybenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Bromo-2-fluoro-3-methoxybenzonitrile is used as a reagent in the synthesis of piperazinopiperazines and related compounds as renal outer medullary potassium (ROMK) channel inhibitors.

Technology Process of 4-Bromo-2-fluoro-3-methoxybenzonitrile

There total 6 articles about 4-Bromo-2-fluoro-3-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2-fluoro-3-methoxybenzoic acid (194804-92-7) → 4-bromo-2-fluoro-3-methoxybenzonitrile (1426073-33-7)

Guidance literature:

4-bromo-2-fluoro-3-methoxybenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 25 ℃; for 2h;

With ammonium hydroxide; In acetonitrile; for 2h;

With 1,3,5-trichloro-2,4,6-triazine; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

Reference yield:

1-fluoro-2-methoxy-3-nitrobenzene (484-94-6) → 4-bromo-2-fluoro-3-methoxybenzonitrile (1426073-33-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / 2844.39 Torr

2.1: sodium nitrite / water / 1 h / -5 - 0 °C

2.2: 2 h / 0 - 50 °C

3.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -70 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 25 °C

4.2: 2 h

4.3: 2 h / 0 °C

With n-butyllithium; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; diisopropylamine; N,N-dimethyl-formamide; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

2-fluoro-6-nitrophenol (1526-17-6,34470-85-4) → 4-bromo-2-fluoro-3-methoxybenzonitrile (1426073-33-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 - 60 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / 2844.39 Torr

3.1: sodium nitrite / water / 1 h / -5 - 0 °C

3.2: 2 h / 0 - 50 °C

4.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -70 °C

5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 25 °C

5.2: 2 h

5.3: 2 h / 0 °C

With n-butyllithium; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; diisopropylamine; N,N-dimethyl-formamide; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

1-fluoro-2-methoxy-3-nitrobenzene

2-fluoro-6-nitrophenol

3-fluoro-2-methoxyaniline

1-bromo-3-fluoro-2-methoxybenzene