2-Fluoro-6-nitroanisole

Base Information

• Chemical Name: 2-Fluoro-6-nitroanisole
• CAS No.: 484-94-6
• Molecular Formula: C7H6FNO3
• Molecular Weight: 171.128
• Hs Code.: 2909309090
• Mol file: 484-94-6.mol

Synonyms:Anisole,2-fluoro-6-nitro- (6CI,8CI);1-Fluoro-2-methoxy-3-nitrobenzene;2-Fluoro-6-nitroanisole;1-fluoro-2-methoxy-3-nitrobenzene;2-Fluoro-6-nitro anisole;2-Fluoro-6-nitrophenyl methyl ether;benzene, 1-fluoro-2-methoxy-3-nitro-;

Chemical Property of 2-Fluoro-6-nitroanisole

Chemical Property:

• Vapor Pressure: 0.0142mmHg at 25°C
• Melting Point: 9 °C
• Refractive Index: 1.521
• Boiling Point: 266.4 °C at 760 mmHg
• Flash Point: 114.9 °C
• PSA: 55.05000
• Density: 1.321 g/cm³
• LogP: 2.26570
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

2-Fluoro-6-nitroanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluoro-6-nitroanisole is a derivative of 2-Fluoro-6-nitrophenol (F594845). Used as plant growth regulators.

Technology Process of 2-Fluoro-6-nitroanisole

There total 8 articles about 2-Fluoro-6-nitroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2-Nitroanisole (91-23-6) → 1-fluoro-2-methoxy-3-nitrobenzene (484-94-6)

Guidance literature:

With acetyl hypofluorite; In dichloromethane; trichlorofluoromethane; at -75 ℃;

DOI:10.1021/jo00179a012

Reference yield:

2-fluoro-6-nitrophenol (1526-17-6,34470-85-4) + dimethyl sulfate (77-78-1) → 1-fluoro-2-methoxy-3-nitrobenzene (484-94-6)

Guidance literature:

With potassium carbonate; xylene;

DOI:10.1021/ja01510a021

Reference yield:

2-fluoro-6-nitrophenol (1526-17-6,34470-85-4) + methyl iodide (74-88-4) → 1-fluoro-2-methoxy-3-nitrobenzene (484-94-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 3h;

upstream raw materials:

2-fluoro-6-nitrophenol

dimethyl sulfate

2-Nitroanisole

1-fluoro-2-methoxybenzene

Downstream raw materials:

4-bromo-2-fluoro-3-methoxybenzonitrile

4-(3,5-difluoro-4-methoxy-phenoxy)-3,5-diiodo-aniline; hydrochloride

4,4'-dimethoxy-3,3',5,5'-tetrafluoroazoxybenzene

5-(2,6-diiodo-4-nitro-phenoxy)-1,3-difluoro-2-methoxy-benzene

Refernces

• 1、 -. "INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL". . . Retrieved 2014/09/03.
• 2、 Wang, Qiuping,Lucien, Edlaine,Hashimoto, Akihiro,Pais, Godwin C. G.,Nelson, David M.,Song, Yongsheng,Thanassi, Jane A.,Marlor, Christopher W.,Thoma, Christy L.,Cheng, Jijun,Podos, Steven D.,Ou, Yangsi,Deshpande, Milind,Pucci, Michael J.,Buechter, Douglas D.,Bradbury, Barton J.,Wiles, Jason A.. "Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: Effects of structural modifications at the 6-, 7-, and 8-positions". . p. 199 - 210. Retrieved 2007/10/03.