3-Fluoro-2-methoxyaniline

Base Information

• Chemical Name: 3-Fluoro-2-methoxyaniline
• CAS No.: 437-83-2
• Molecular Formula: C7H8FNO
• Molecular Weight: 141.145
• Hs Code.: 2922299090
• Mol file: 437-83-2.mol

Synonyms:o-Anisidine,3-fluoro- (8CI);2-Amino-6-fluoroanisole;3-Fluoro-2-methoxyaniline;3-Fluoro-2-methoxyphenylamine;

Chemical Property of 3-Fluoro-2-methoxyaniline

Chemical Property:

• Appearance/Colour: Brown crystal
• Vapor Pressure: 0.129mmHg at 25°C
• Melting Point: 162 °C
• Refractive Index: n20/D 1.446(lit.)
• Boiling Point: 217.9 °C at 760 mmHg
• PKA: 3.52±0.10(Predicted)
• Flash Point: 42.2 °C
• PSA: 35.25000
• Density: 1.176g/cm³
• LogP: 1.99770
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

3-Fluoro-2-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F; Xi
• Hazard Codes: F,Xi,T
• Statements: 11-36/37/38-24/25
• Safety Statements: 16-26-36-45-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Fluoro-2-methoxyaniline is a reactant in the synthesis of hydroxyquinolines.

Technology Process of 3-Fluoro-2-methoxyaniline

There total 8 articles about 3-Fluoro-2-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-fluoro-2-methoxy-3-nitrobenzene (484-94-6) → 3-fluoro-2-methoxyaniline (437-83-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 24h;

Reference yield: 86.0%

bromo-4 fluoro-2 nitro-6 anisole (74266-66-3) → 3-fluoro-2-methoxyaniline (437-83-2)

Guidance literature:

With potassium hydroxide; hydrogen; palladium on activated charcoal; In methanol; for 1h; under 60004.8 - 75005.9 Torr;

Reference yield:

2-fluoro-6-nitrophenol (1526-17-6,34470-85-4) → 3-fluoro-2-methoxyaniline (437-83-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dimethylformamide / 6 h / 80 °C

2: H₂ / Pd/C / methanol / 27 h / 20 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm060844e

upstream raw materials:

1-fluoro-2-methoxy-3-nitrobenzene

bromo-4 fluoro-2 nitro-6 anisole

2-fluoro-6-nitrophenol

4-bromo-2-fluorophenol

Downstream raw materials:

1,3-difluoro-2-methoxybenzene

4-nitro-benzoic acid-(3-fluoro-2-methoxy-anilide)

fluoro-3 methoxy-2 benzaldehhyde

1-fluoro-3-iodo-2-methoxybenzene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 437-83-2 3-Fluoro-2-methoxyaniline

Send

Send

Metric Ton KG G Pound L ML

Send

Send