5-METHOXY-3-PIPERIDIN-4-YL-1H-INDOLE

Base Information

• Chemical Name: 5-METHOXY-3-PIPERIDIN-4-YL-1H-INDOLE
• CAS No.: 52157-82-1
• Molecular Formula: C14H18 N2 O
• Molecular Weight: 230.31
• Mol file: 52157-82-1.mol

Synonyms:4-(5-Methoxy-3-indolyl)piperidine;5-Methoxy-3-(4-piperidinyl)-1H-indole; 5-Methoxy-3-(4-piperidinyl)indole

Chemical Property of 5-METHOXY-3-PIPERIDIN-4-YL-1H-INDOLE

Chemical Property:

• Vapor Pressure: 2.19E-07mmHg at 25°C
• Melting Point: 152-153℃
• Boiling Point: 423.7°Cat760mmHg
• Flash Point: 210°C
• PSA: 37.05000
• Density: 1.133g/cm³
• LogP: 2.97230
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

5-Methoxy-3-piperidin-4-yl-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHOXY-3-PIPERIDIN-4-YL-1H-INDOLE

There total 16 articles about 5-METHOXY-3-PIPERIDIN-4-YL-1H-INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (66611-26-5) → 4-(5-methoxy-1H-indol-3-yl)piperidine (52157-82-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; for 24h; under 760.051 Torr;

Reference yield: 95.0%

tert-butyl-4-(5-methoxy-1H-indol-3-yl)piperidine-1-carboxylate (951174-11-1) → 4-(5-methoxy-1H-indol-3-yl)piperidine (52157-82-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2007.08.038

Reference yield: 83.0%

5-methoxylindole (1006-94-6) + 4-piperidone monohydrochloride monohydrate (40064-34-4,320589-77-3) → 4-(5-methoxy-1H-indol-3-yl)piperidine (52157-82-1)

Guidance literature:

upstream raw materials:

3-(1-acetyl-4-piperidyl)-5-methoxyindole

5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole

tert-butyl-4-(5-methoxy-1H-indol-3-yl)piperidine-1-carboxylate

5-methoxylindole

Downstream raw materials:

(E)-3-(3,4-dichlorophenyl)-N-{5-[4-(5-methoxy-1H-indol-3-yl)-piperidin-1-yl]pentyl}acrylamide

5-methoxy-3-<1-<2-<1-phenyl-1H-pyrazol-4-yl>ethyl>-4-piperidinyl>-1H-indole

8-[4-{4-(5-methoxy-1H-indol-3-yl)-1-piperidinyl}-butyl]-8-azaspiro[4,5]decane-7,9-dione

2-{4-[4-(5-methoxy-1H-indol-3-yl)piperidin-1-yl]-butyl}-4-phenylpyrido[1,2-c]pyrimidine-1,3-dione

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