66611-26-5

Basic information

• Product Name: 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
• Synonyms: 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole;3-(1,2,3,6-Tetrahydropyridine-4-yl)-5-methoxy-1H-indole;5-Methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole succinate;5,6-dimethyl-2-(pyridin-4-yl)-2,3-dihydro-1H-benzo[d]imidazole
• CAS NO: 66611-26-5
• Molecular Formula: C₁₄H₁₆N₂O
• Molecular Weight: 228.29
• Mol File: 66611-26-5.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole(66611-26-5)
• EPA Substance Registry System: 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole(66611-26-5)

Safety Data

• Hazardous Substances Data: 66611-26-5(Hazardous Substances Data)

Usage

General Description

5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole is a chemical compound that belongs to the class of indole derivatives. It is a synthetic compound with potential pharmacological applications. The presence of a methoxy group at the 5-position of the indole ring and a tetrahydropyridine group attached to the 3-position gives this compound unique properties and potential biological activities. This chemical structure may be of interest in medicinal chemistry and drug development, with potential applications in the treatment of various diseases and conditions. Further research on its pharmacological properties and biological activities may lead to its potential use as a therapeutic agent in the future.

Upstream product

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• 1336-21-6 ammonium hydroxide 

Downstream Products

• 72808-65-2 5-methoxy-3-(1-propyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole 
• 52157-82-1 4-(5-methoxy-1H-indol-3-yl)piperidine 

Relevant articles and documents

Synthesis and biological evaluation of novel pyrrolidine-2,5-dione derivatives as potential antidepressant agents. Part 1

A series of 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives was synthesized and their biological activity was evaluated. The chemical structures of the newly prepared compounds were confirmed by 1H NMR, 13C NMR and ESI-HRMS spectra data. All tested compounds proved to be potent 5-HT1A receptor and serotonin transporter protein (SERT) ligands. Among them, compounds 15, 18, 19 and 30 showed significant affinity for 5-HT1A and SERT. Computer docking simulations carried out for compounds 15, 31 and 32 to models of 5-HT1A receptor and SERT confirm the results of biological tests. Due to high affinity for the 5-HT1A receptor and moderate affinity for SERT, compounds 31, 32, 35, and 37 were evaluated for their affinity for D2L, 5-HT6, 5-HT 7 and 5-HT2A receptors. In vivo tests, in turn, resulted in determining the functional activity of compounds 15, 18, 19 and 30 to the 5-HT1A receptor. The results of these tests indicate that all of the ligands possess properties characteristic of 5-HT1A receptor agonists.

2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT 6 receptor agonists

A series of 2-alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles were synthesized and evaluated for their 5-HT6 activity. The most potent agonist in this series was 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)- 1H-indole with an ICsub

ARYL PIPERIDINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA

This invention relates to novel compounds which up-regulate LDL receptor (LDL-r) expression and to processes for their preparation, pharmaceutical compositions containing them and their medical use. More particularly, this invention relates to novel aromatic piperidines of formula (I) and their use in therapy.