2-Methoxybenzhydryl alcohol

Base Information

• Chemical Name: 2-Methoxybenzhydryl alcohol
• CAS No.: 22788-49-4
• Molecular Formula: C14H14 O2
• Molecular Weight: 214.264
• Hs Code.: 2909499000
• European Community (EC) Number: 245-218-9
• NSC Number: 92806
• DSSTox Substance ID: DTXSID501300309
• Nikkaji Number: J286.305G
• Mol file: 22788-49-4.mol

Synonyms:22788-49-4;(2-methoxyphenyl)(phenyl)methanol;2-Methoxybenzhydryl alcohol;(2-methoxyphenyl)-phenylmethanol;EINECS 245-218-9;2-Methoxybenzhydrol;NSC92806;SCHEMBL477540;2-methoxyphenyl(phenyl)methanol;DTXSID501300309;2-Methoxy-alpha-phenylbenzenemethanol;NSC 92806;NSC-92806;BB 0258790;EN300-110268

Chemical Property of 2-Methoxybenzhydryl alcohol

Chemical Property:

• Vapor Pressure: 5.02E-06mmHg at 25°C
• Boiling Point: 366.8°Cat760mmHg
• Flash Point: 167°C
• PSA: 29.46000
• Density: 1.121g/cm³
• LogP: 2.77690
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 214.099379685
• Heavy Atom Count: 16
• Complexity: 199

Purity/Quality:

99% ^*data from raw suppliers

2-Methoxybenzhydrylalcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C(C2=CC=CC=C2)O

Technology Process of 2-Methoxybenzhydryl alcohol

There total 30 articles about 2-Methoxybenzhydryl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromoanisole (578-57-4) + benzaldehyde (100-52-7) → 2-methoxyphenyl(phenyl)methanol (22788-49-4)

Guidance literature:

2-bromoanisole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

benzaldehyde; In tetrahydrofuran; hexane; at -78 - 22 ℃; for 20h; Inert atmosphere;

DOI:10.1021/jacs.6b05820

Reference yield: 100.0%

2-Chloroanisole (766-51-8) + benzaldehyde (100-52-7) → 2-methoxyphenyl(phenyl)methanol (22788-49-4)

Guidance literature:

2-Chloroanisole; With iodine; magnesium; In tetrahydrofuran; at 150 ℃; for 1h; Inert atmosphere; Microwave irradiation;

benzaldehyde; In tetrahydrofuran; at 100 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.bmcl.2010.02.022

Reference yield: 99.0%

ortho-anisaldehyde (135-02-4) + phenylboronic acid (98-80-6) → 2-methoxyphenyl(phenyl)methanol (22788-49-4)

Guidance literature:

With potassium fluoride; cyclopalladated ferrocenylimine bipyridine complex; In water; at 100 ℃; for 12h;

DOI:10.1016/j.tetlet.2008.07.003

upstream raw materials:

ortho-methoxybenzophenone

(2-methoxy-phenyl)-trimethyl-silane

benzaldehyde

ortho-anisaldehyde

Downstream raw materials:

3-hydroxy-3-(2-methoxy-phenyl)-3-phenyl-propionic acid ethyl ester

N-((2-methoxyphenyl)(phenyl)methyl)benzamide

1-methoxy-2-(1-phenylbut-3-enyl)phenol

3-Phenylbenzofuran