2-Methoxybenzophenone

Base Information

• Chemical Name: 2-Methoxybenzophenone
• CAS No.: 2553-04-0
• Molecular Formula: C14H12 O2
• Molecular Weight: 212.248
• Hs Code.: 2914790090
• European Community (EC) Number: 219-857-9
• NSC Number: 408008
• UNII: 4YN2FZ8JC8
• DSSTox Substance ID: DTXSID70180227
• Nikkaji Number: J105.150D
• Wikidata: Q63392426
• Mol file: 2553-04-0.mol

Synonyms:2-Methoxybenzophenone;2553-04-0;(2-Methoxyphenyl)(phenyl)methanone;o-Methoxybenzophenone;Benzophenone, 2-methoxy-;(2-methoxyphenyl)-phenylmethanone;Methanone, (2-methoxyphenyl)phenyl-;4YN2FZ8JC8;(2-methoxyphenyl)phenylmethanone;EINECS 219-857-9;MFCD00017163;NSC-408008;methoxybenzophenone;NSC408008;2-BENZOYLANISOLE;Maybridge1_005821;UNII-4YN2FZ8JC8;SCHEMBL50229;BENZOPHENONE, O-METHOXY-;HMS558A13;DTXSID70180227;2-methoxybenzophenone, AldrichCPR;(2-Methoxy-phenyl)-phenylmethanon;(2-Methoxy-phenyl)-phenylmethanone;Methanone,(2-methoxyphenyl)phenyl-;CCG-51677;PHENYL 2-METHOXYPHENYL KETONE;AKOS009157474;NSC 408008;PS-7986;(2-METHOXYPHENYL)PHENYL METHANONE;CS-0316301;FT-0612824;SR-01000640966-1;Q63392426

Chemical Property of 2-Methoxybenzophenone

Chemical Property:

• Vapor Pressure: 1.25E-05mmHg at 25°C
• Melting Point: 36-38°C
• Refractive Index: 1.6000 (estimate)
• Boiling Point: 149-150°C 1mm
• Flash Point: 171.7°C
• PSA: 26.30000
• Density: 1.108g/cm³
• LogP: 2.92620
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 212.083729621
• Heavy Atom Count: 16
• Complexity: 231

Purity/Quality:

99% ^*data from raw suppliers

2-Methoxybenzophenone ^*data from reagent suppliers

Safty Information:

• Statements: 52
• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C(=O)C2=CC=CC=C2

Technology Process of 2-Methoxybenzophenone

There total 139 articles about 2-Methoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzoyl chloride (98-88-4) + methoxybenzene (100-66-3) → 4-Methoxybenzophenone (611-94-9) + ortho-methoxybenzophenone (2553-04-0)

Guidance literature:

With 12-Tungstophosphoric acid niched in Zr-based metal-organic framework; at 120 ℃; for 6h; under 760.051 Torr; Reagent/catalyst;

DOI:10.1007/s11426-017-9182-0

Reference yield: 92.0%

benzoyl chloride (98-88-4) + methoxybenzene (100-66-3) → 4-Methoxybenzophenone (611-94-9) + ortho-methoxybenzophenone (2553-04-0) + 3-methoxybenzophenone (6136-67-0)

Guidance literature:

With rhenium(I) pentacarbonyl bromide; In 1,2-dichloro-ethane; for 2h; Heating;

DOI:10.1246/bcsj.68.2379

Reference yield: 92.0%

methoxybenzene (100-66-3) + benzoic acid anhydride (93-97-0) → 4-Methoxybenzophenone (611-94-9) + ortho-methoxybenzophenone (2553-04-0) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With Cl^(1-)*C₅H₁₄NO⁽¹⁺⁾*3ZnCl₂; at 120 ℃; for 0.0833333h; regioselective reaction; Microwave irradiation; Green chemistry;

DOI:10.1039/c6ra03551e

upstream raw materials:

diazomethane

methanol

2-Hydroxybenzophenone

methyl bromide

Downstream raw materials:

1-(2-methoxy-phenyl)-1-phenyl-ethanol

2-(1-phenylvinyl)anisole

N-(3-Dimethylaminopropyl)-2-methoxy-diphenylketoimin

2-methoxyphenyl(phenyl)methanol

Refernces

• 1、 Kalena,Jadhav,Banerji. "DDQ/PbO2: A novel oxidation system for hindered electron rich benzhydrols". . p. 240 - 244. Retrieved 2000.
• 2、 Wine,Tessonnier,Pham-Huu,Ledoux. "Beta zeolite supported on a macroscopic pre-shaped SiC as a high performance catalyst for liquid-phase benzoylation". . p. 2418 - 2419. Retrieved 2002.
• 3、 Ullah, Latif,Zhao, Guoying,Xu, Zichen,He, Hongyan,Usman, Muhammad,Zhang, Suojiang. "12-Tungstophosphoric acid niched in Zr-based metal-organic framework: a stable and efficient catalyst for Friedel-Crafts acylation". . p. 402 - 411. Retrieved 2018.
• 4、 Ma, Yangmin,Shao, Lei,Szostak, Michal,Wang, Ruihong,Zhang, Jin,Zhang, Pei. "Mechanochemical Solvent-Free Suzuki–Miyaura Cross-Coupling of Amides via Highly Chemoselective N?C Cleavage". supporting information. . Retrieved 2022/01/04.
• 5、 Lin, Shih-Chieh Aaron,Liu, Shiuh-Tzung,Liu, Yi-Hung,Peng, Shie-Ming,Su, Bo-Kai. "Tetra- And Dinuclear Palladium Complexes Based on a Ligand of 2,8-Di-2-pyridinylanthyridine: Preparation, Characterization, and Catalytic Activity". . p. 2081 - 2089. Retrieved 2021/07/26.