diethyl 2-(4-(3-bromo-4-methoxyphenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Base Information

Chemical Name:diethyl 2-(4-(3-bromo-4-methoxyphenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate
CAS No.:1035261-13-2
Molecular Formula:C20H25BrO7
Molecular Weight:457.31
Hs Code.:
Mol file:1035261-13-2.mol

Synonyms:diethyl 2-(4-(3-bromo-4-methoxyphenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Suppliers and Price of diethyl 2-(4-(3-bromo-4-methoxyphenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 2-(4-(3-bromo-4-methoxyphenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Chemical Property:

PSA：88.13000
LogP:2.81740

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of diethyl 2-(4-(3-bromo-4-methoxyphenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

There total 4 articles about diethyl 2-(4-(3-bromo-4-methoxyphenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₄BrClO₃

: 105-53-3
diethyl malonate

: 1035261-13-2
diethyl 2-(4-(3-bromo-4-methoxyphenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Guidance literature:: diethyl malonate; With triethylamine; magnesium chloride; In acetonitrile; at 0 - 20 ℃; for 2.5h;

C₁₃H₁₄BrClO₃; In acetonitrile; at 50 ℃; for 15h;

Reference yield:

: 1035261-12-1
4-(3-bromo-4-methoxyphenyl)-tetrahydro-2H-pyran-4-carboxylic acid

: 1035261-13-2
diethyl 2-(4-(3-bromo-4-methoxyphenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 2 h / Heating / reflux

2.1: triethylamine; magnesium chloride / acetonitrile / 2.5 h / 0 - 20 °C

2.2: 15 h / 50 °C

With thionyl chloride; triethylamine; magnesium chloride; In acetonitrile;

Reference yield:

: 1035261-11-0
4-(3-bromo-4-methoxyphenyl)-tetrahydro-2H-pyran-4-carbonitrile

: 1035261-13-2
diethyl 2-(4-(3-bromo-4-methoxyphenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; water / 0.5 h / 180 °C

2.1: thionyl chloride / 2 h / Heating / reflux

3.1: triethylamine; magnesium chloride / acetonitrile / 2.5 h / 0 - 20 °C

3.2: 15 h / 50 °C

With thionyl chloride; sulfuric acid; water; triethylamine; magnesium chloride; In acetonitrile;