2,6-Difluoro-4-ethoxybenzoic acid

Base Information

• Chemical Name: 2,6-Difluoro-4-ethoxybenzoic acid
• CAS No.: 916483-56-2
• Molecular Formula: C9H8F2O3
• Molecular Weight: 202.158
• Hs Code.: 2918990090
• Mol file: 916483-56-2.mol

Synonyms:2,6-Difluoro-4-ethoxybenzoic acid

Chemical Property of 2,6-Difluoro-4-ethoxybenzoic acid

Chemical Property:

• PSA: 46.53000
• LogP: 2.06170

Purity/Quality:

99% ^*data from raw suppliers

4-Ethoxy-2,6-difluorobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Difluoro-4-ethoxybenzoic acid

There total 3 articles about 2,6-Difluoro-4-ethoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3,5-difluorophenyl ethyl ether (144891-25-8) + carbon dioxide (124-38-9,18923-20-1) → 4-ethoxy-2,6-difluorobenzoic acid (916483-56-2)

Guidance literature:

3,5-difluorophenyl ethyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

carbon dioxide; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;

DOI:10.1080/00397910802219247

Reference yield:

3,5-difluorophenol (2713-34-0) → 4-ethoxy-2,6-difluorobenzoic acid (916483-56-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / 0 - 80 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 2 h / -78 °C

2.2: 20 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexanes; N,N-dimethyl-formamide;

Reference yield:

ethyl bromide (74-96-4) + 2,6-difluoro-4-hydroxybenzoic acid (214917-68-7) → 4-ethoxy-2,6-difluorobenzoic acid (916483-56-2)

Guidance literature:

2,6-difluoro-4-hydroxybenzoic acid; With potassium hydroxide; In ethanol; water; Reflux;

ethyl bromide; In ethanol; water; Heating;

With hydrogenchloride; In ethanol; water;

DOI:10.1080/15421400802198359

upstream raw materials:

3,5-difluorophenyl ethyl ether

carbon dioxide

ethyl bromide

2,6-difluoro-4-hydroxybenzoic acid

Downstream raw materials:

C₂₄H₁₈F₄O₆

4-ethoxy-2,6-difluorobenzamide

2-amino-4-ethoxy-6-fluorobenzonitrile

4-ethoxy-2,6-difluorobenzonitrile

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