Azetidin-2-ylmethanol

Base Information

• Chemical Name: Azetidin-2-ylmethanol
• CAS No.: 250274-91-0
• Molecular Formula: C₄H₉NO
• Molecular Weight: 87.1216
• Hs Code.: 2905599890
• European Community (EC) Number: 810-749-2
• DSSTox Substance ID: DTXSID40570479
• Mol file: 250274-91-0.mol

Synonyms:Azetidin-2-ylmethanol;250274-91-0;AZETIDINE-2-METHANOL;Azetidin-2-yl-methanol;(Azetidin-2-yl)methanol;MFCD12406977;MFCD10565789;MFCD10565790;2-hydroxymethylazetidine;2-AZETIDINYLMETHANOL;(R)-2-(Hydroxymethyl)azetidine;(S)-2-(Hydroxymethyl)azetidine;DTXSID40570479;FTWWNKCHSPDIQW-UHFFFAOYSA-N;AKOS015907351;PB13255;PB21145;SB44679;PS-17318;SY008233;SY036513;SY036514;CS-0049913;EN300-154332

Chemical Property of Azetidin-2-ylmethanol

Chemical Property:

• Boiling Point: 151.9±13.0 °C(Predicted)
• PKA: 14.77±0.10(Predicted)
• PSA: 32.26000
• Density: 1.017±0.06 g/cm3(Predicted)
• LogP: -0.33060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 87.068413911
• Heavy Atom Count: 6
• Complexity: 46.8

Purity/Quality:

97% ^*data from raw suppliers

Azetidin-2-ylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNC1CO

Technology Process of Azetidin-2-ylmethanol

There total 7 articles about Azetidin-2-ylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl (2R)-4-oxoazetidine-2-carboxylate (95729-87-6) → (2R)-2-azetidinylmethanol (209329-11-3,250274-91-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/S0957-4166(98)00291-2

Reference yield:

(2S)-azetidine-2-carboxylic acid (2133-34-8,20063-89-2) → (S)-azetidine-2-methanol (104587-62-4,250274-91-0)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1055/s-1998-1858

Reference yield:

azetidine-2-carboxylic acid ethyl ester (766483-76-5,790165-87-6) → azetidin-2-ylmethanol (104587-62-4,250274-91-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 70 ℃; for 3h;

upstream raw materials:

azetidine

formaldehyd

azetidine-2-carboxylic acid ethyl ester

azetidine-2-carboxylic acid methyl ester hydrochloride

Downstream raw materials:

(R)-1-t-butyloxycarbonyl-2-azetidinemethanol

2-(S)-hydroxymethyl-azetidine-1-carboxylic acid tert-butyl ester