34529-06-1

Basic information

• Product Name: 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER
• Synonyms: 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER;3-Amino-phthalic acid dimethyl ester;3-Amino-1,2-benzenedicarboxylic acid 1,2-dimethyl ester;dimethyl 3-aminophthalate;Methyl 3-amino-2-(methoxycarbonyl)benzoate;1,2-diMethyl 3-aMinobenzene-1,2-dicarboxylate;1,2-Benzenedicarboxylicacid, 3-aMino-, 1,2-diMethyl ester;DiMethyl 3-aMino-1,2-benzenedicarboxylate
• CAS NO: 34529-06-1
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.2
• EINECS: 200-258-5
• Mol File: 34529-06-1.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 306℃
• Flash Point: 136℃
• Appearance: /
• Density: 1.248
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.05±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER(34529-06-1)
• EPA Substance Registry System: 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER(34529-06-1)

Safety Data

• Hazardous Substances Data: 34529-06-1(Hazardous Substances Data)

Usage

Uses

Dimethyl 3-aminophthalate is a useful research chemical.

InChI:InChI=1/C10H11NO4/c1-14-9(12)6-4-3-5-7(11)8(6)10(13)15-2/h3-5H,11H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 641-70-3 3-nitrophthalic acid anhydride 
• 108-24-7 acetic anhydride 
• 22351-62-8 3-nitro-phthalic acid-1-chloride-2-methyl ester 
• 6744-85-0 2-(methoxycarbonyl)-3-nitrobenzoic acid 
• 603-11-2 3-nitrophthalic acid 
• 75-03-6 ethyl iodide 
• 24564-71-4 3-Nitrophthaloyl dichloride 
• 110036-10-7 3-Amino-4-triisopropylsilanyl-phthalic acid dimethyl ester 
• 13365-26-9 dimethyl 3-nitrophthalate 

Downstream Products

• 83647-42-1 3-amino-2-methylbenzyl alcohol 
• 98593-50-1 2,3-bis-hydroxymethyl-aniline 
• 58749-33-0 dimethyl 3-bromophthalate 
• 103856-64-0 dimethyl 3-cyanobenzene-1,2-dicarboxylate 
• 34529-07-2 3-morpholin-4-yl-phthalic acid dimethyl ester 
• 927672-45-5 C₁₄H₁₇NO₄ 

Relevant articles and documents

Designed, synthesized and biological evaluation of proteolysis targeting chimeras (PROTACs) as AR degraders for prostate cancer treatment

As a continuation of our research on developing potent and potentially safe androgen receptor (AR) degrader, a series of novel proteolysis targeting chimeras (PROTACs) containing the phthalimide degrons with different linker were designed, synthesized and evaluated for their AR degradation activity against LNCaP (AR+) cell line. Most of the synthesized compounds displayed moderate to satisfactory AR binding affinity and might lead to antagonist activity against AR. Among them, compound A16 exhibited the best AR binding affinity (85%) and degradation activity against AR. Due to the strong fluorescence properties of pomalidomide derivatives, B10 was found to be effectively internalized and visualized in LNCaP (AR + ) cells than PC-3 (AR-) cells. Moreover, the molecular docking of A16 with AR and the active site of DDB1-CRBN E3 ubiquitin ligase complex provides guidance to design new PROTAC degrons targeting AR for prostate cancer therapy. These results represent a step toward the development of novel and improved AR PROTACs.

Method for preparing dimethyl aminophthalate

The invention relates to a method for preparing dimethyl aminophthalate. The method comprises the following steps: dissolving nitrophthalic anhydride in methanol, adding a graphite-phase carbon nitride supported cuprous catalyst (g-C3N4/Cu2O) and a catalytic amount of acetic anhydride, and carrying out reacting to obtain dimethyl aminophthalate, wherein 200-300 mg of the graphite-phase carbon nitride supported cuprous catalyst (g-C3N4/Cu2O) is used for every millimole of nitrophthalic anhydride, and 0.05-0.08 mmol of acetic anhydride is used for every millimole of nitrophthalic anhydride.

AZA-PHENALENE-3-KETONE DERIVATIVE, PREPARATION METHOD THEREOF, AND ITS APPLICATION AS PARP INHIBITOR

Disclosed are an aza-phenalene-3-ketone derivative, a preparation method thereof and its application as a PARP inhibitor. The aza-phenalene-3-ketone derivative has the following structure: wherein R is hydrogen, methyl, ethyl, isopropyl, benzyl or 3-methyl-3-butenyl. The aza-phenalene-3-ketone derivative has very high activity for inhibiting PARP, thereby providing a good basis for new drug research of developing a nitrogen-doped phenalene-3-ketone compound as PARP inhibitor to treat cancer.