2,4-Bis(trifluoromethyl)benzeneboronic acid pinacol ester

Base Information

• Chemical Name: 2,4-Bis(trifluoromethyl)benzeneboronic acid pinacol ester
• CAS No.: 1073353-65-7
• Molecular Formula: C14H17BF6O3
• Molecular Weight: 358.0843992
• Hs Code.: 2934999090
• Mol file: 1073353-65-7.mol

Synonyms:2,4-Bis(trifluoromethyl)benzeneboronic acid pinacol ester;2,4-BIS(TRIFLUOROMETHYL)PHENYLBORONIC ACID, PINACOL ESTER;2-(2,4-Bis(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of 2,4-Bis(trifluoromethyl)benzeneboronic acid pinacol ester

Chemical Property:

• Boiling Point: 79-81°C/1mm
• Flash Point: 79-81°C/1mm
• PSA: 18.46000
• LogP: 4.02340
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,4-Bis(trifluoromethyl)phenylboronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Bis(trifluoromethyl)phenylboronic acid, pinacol ester

Technology Process of 2,4-Bis(trifluoromethyl)benzeneboronic acid pinacol ester

There total 2 articles about 2,4-Bis(trifluoromethyl)benzeneboronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (61676-62-8) + 1,3-bis(trifluoromethyl)benzene (402-31-3) → 2-(2,6-bis(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1268693-25-9) + 4,4,5,5-tetramethyl-2-(2,4-bis(trifluoromethyl)phenyl)-1,3,2-dioxaborolane (1073353-65-7)

Guidance literature:

1,3-bis(trifluoromethyl)benzene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 1.66667h; Inert atmosphere;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; at -78 - 0 ℃;

DOI:10.1071/CH13642

Reference yield: 31.0%

1,3-bis(trifluoromethyl)benzene (402-31-3) + bis(pinacol)diborane (73183-34-3) → 2-(2,6-bis(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1268693-25-9) + 4,4,5,5-tetramethyl-2-(2,4-bis(trifluoromethyl)phenyl)-1,3,2-dioxaborolane (1073353-65-7)

Guidance literature:

1,3-bis(trifluoromethyl)benzene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 1.66667h; Inert atmosphere;

bis(pinacol)diborane; at -78 - 0 ℃;

DOI:10.1071/CH13642

Reference yield: 65.0%

2-bromo-4-aminopyridine (7598-35-8) + 4,4,5,5-tetramethyl-2-(2,4-bis(trifluoromethyl)phenyl)-1,3,2-dioxaborolane (1073353-65-7) → 4-amino-2-(2,4-bis(trifluoromethyl)phenyl)pyridine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; methanol; water; at 100 ℃; for 3h; Microwave irradiation;

DOI:10.1021/acs.inorgchem.6b02088

upstream raw materials:

1,3-bis(trifluoromethyl)benzene

bis(pinacol)diborane

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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