Iso Rizatriptan

Base Information

Chemical Name:Iso Rizatriptan
CAS No.:208941-96-2
Molecular Formula:C₁₅H₁₉N₅
Molecular Weight:269.349
Hs Code.:
Mol file:208941-96-2.mol

Synonyms:Iso Rizatriptan;N,N-DiMethyl-5-(1H-1,2,4-triazol-1-ylMethyl)-;Rizatriptan IMpurity C

Suppliers and Price of Iso Rizatriptan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
IsoRizatriptan
2.5mg
$ 275.00

Biosynth Carbosynth
IsoRizatriptan
2 mg
$ 408.80

Biosynth Carbosynth
IsoRizatriptan
10 mg
$ 1351.40

Biosynth Carbosynth
IsoRizatriptan
25 mg
$ 2457.00

Biosynth Carbosynth
IsoRizatriptan
1 mg
$ 224.90

Biosynth Carbosynth
IsoRizatriptan
5 mg
$ 743.30

American Custom Chemicals Corporation
RIZATRIPTAN IMPURITY C 95.00%
5MG
$ 498.80

AK Scientific
N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-2-ethanamine
25mg
$ 3366.00

AK Scientific
N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-2-ethanamine
10mg
$ 1874.00

AK Scientific
N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-2-ethanamine
5mg
$ 1053.00

Total 10 raw suppliers

Chemical Property of Iso Rizatriptan

Chemical Property:

Melting Point:96-98°C
Boiling Point:504.8±60.0 °C(Predicted)
PKA:17.16±0.30(Predicted)
PSA：49.74000
Density:1.21±0.1 g/cm3(Predicted)
LogP:1.91180
Storage Temp.:Refrigerator
Solubility.:Acetonitrile (Slightly), DMSO (Slightly), Methanol

Purity/Quality:

99%, ^*data from raw suppliers

IsoRizatriptan ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Iso Rizatriptan (Rizatriptan EP Impurity C) is a potential impurity of Rizatriptan. A regioisomer of Rizatriptan. A potential impurity of Rizatriptan. A regioisomer of Rizatriptan.

Technology Process of Iso Rizatriptan

There total 8 articles about Iso Rizatriptan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1364692-31-8
tert-butyl 5-((1H-1,2,4-triazol-1-yl)-methyl)-2-(2-(dimethylamino)ethyl)-1H-indole-1-carboxylate

: 208941-96-2
2-(5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indol-2-yl)-N,N-dimethylethanamine

Guidance literature:: tert-butyl 5-((1H-1,2,4-triazol-1-yl)-methyl)-2-(2-(dimethylamino)ethyl)-1H-indole-1-carboxylate; With hydrogenchloride; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 0.5h;

With sodium hydrogencarbonate; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/op200284m

Reference yield:

: 1364691-93-9
4-((1H-1,2,4-triazol-1-yl)methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)benzenamine

: 208941-96-2
2-(5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indol-2-yl)-N,N-dimethylethanamine

Guidance literature:: Multi-step reaction with 6 steps

1: tert-butyl alcohol / 15 h / 60 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / Reflux

3: ethanol; toluene-4-sulfonic acid / 15 h

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

5: 5 h / 60 °C

6: hydrogenchloride / tetrahydrofuran; ethyl acetate / 0.5 h / 20 °C

With hydrogenchloride; ethanol; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/op200284m

Reference yield:

: 1364692-00-1
tert-butyl 4-((1H-1,2,4-triazol-1-yl)-methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)-phenylcarbamate

: 208941-96-2
2-(5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indol-2-yl)-N,N-dimethylethanamine

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / Reflux

2: ethanol; toluene-4-sulfonic acid / 15 h

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

4: 5 h / 60 °C

5: hydrogenchloride / tetrahydrofuran; ethyl acetate / 0.5 h / 20 °C

With hydrogenchloride; ethanol; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/op200284m