tert-butyl 4-((1H-1,2,4-triazol-1-yl)-methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)phenylcarbamate

Base Information

Chemical Name:tert-butyl 4-((1H-1,2,4-triazol-1-yl)-methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)phenylcarbamate
CAS No.:1364692-00-1
Molecular Formula:C₂₃H₃₀N₄O₄
Molecular Weight:426.516
Hs Code.:
Mol file:1364692-00-1.mol

Synonyms:tert-butyl 4-((1H-1,2,4-triazol-1-yl)-methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)phenylcarbamate

Suppliers and Price of tert-butyl 4-((1H-1,2,4-triazol-1-yl)-methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)phenylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of tert-butyl 4-((1H-1,2,4-triazol-1-yl)-methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)phenylcarbamate

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-((1H-1,2,4-triazol-1-yl)-methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)phenylcarbamate

There total 4 articles about tert-butyl 4-((1H-1,2,4-triazol-1-yl)-methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1364691-93-9
4-((1H-1,2,4-triazol-1-yl)methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)benzenamine

: 1364692-00-1
tert-butyl 4-((1H-1,2,4-triazol-1-yl)-methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)-phenylcarbamate

Guidance literature:: In tert-butyl alcohol; at 60 ℃; for 15h;
DOI:10.1021/op200284m

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1364692-00-1
tert-butyl 4-((1H-1,2,4-triazol-1-yl)-methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)-phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

3: tert-butyl alcohol / 15 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol; 2: Sonogashira coupling;
DOI:10.1021/op200284m

Reference yield:

: 40365-61-5
2-(but-3-yn-1-yloxy)tetrahydropyran

: 1364692-00-1
tert-butyl 4-((1H-1,2,4-triazol-1-yl)-methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)-phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

2: tert-butyl alcohol / 15 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; tert-butyl alcohol; 1: Sonogashira coupling;
DOI:10.1021/op200284m