4-((1H-1,2,4-triazol-1-yl)methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)benzenamine

Base Information

Chemical Name:4-((1H-1,2,4-triazol-1-yl)methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)benzenamine
CAS No.:1364691-93-9
Molecular Formula:C₁₈H₂₂N₄O₂
Molecular Weight:0
Hs Code.:

Synonyms:4-((1H-1,2,4-triazol-1-yl)methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)benzenamine

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Chemical Property of 4-((1H-1,2,4-triazol-1-yl)methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)benzenamine

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 4-((1H-1,2,4-triazol-1-yl)methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)benzenamine

There total 3 articles about 4-((1H-1,2,4-triazol-1-yl)methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 40365-61-5
2-(but-3-yn-1-yloxy)tetrahydropyran

4-((1H-1,2,4-triazol-1-yl)methyl)-2-iodobenzenamine: 160194-26-3
4-((1H-1,2,4-triazol-1-yl)methyl)-2-iodobenzenamine

: 1364691-93-9
4-((1H-1,2,4-triazol-1-yl)methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)benzenamine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/op200284m

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1364691-93-9
4-((1H-1,2,4-triazol-1-yl)methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)benzenamine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1021/op200284m

Reference yield:

: 119192-10-8
4-(1H-1,2,4-triazol-1-ylmethyl)aniline

: 1364691-93-9
4-((1H-1,2,4-triazol-1-yl)methyl)-2-(4-(tetrahydro-2H-pyran-2-yloxy)but-1-ynyl)benzenamine

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; sodium hydrogencarbonate / water / 30 h

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1021/op200284m