2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one

Base Information

Chemical Name:2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one
CAS No.:1232815-50-7
Molecular Formula:C₇H₇N₃OS
Molecular Weight:181.218
Hs Code.:2933990090
Mol file:1232815-50-7.mol

Synonyms:2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one;2-(Methylthio)pyrrolo[2,1...;2-(methylsulfanyl)-3h,4h-pyrrolo[2,1-f][1,2,4]triazin-4-one;2-(methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Suppliers and Price of 2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one
500mg
$ 330.00

SynQuest Laboratories
2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one
250 mg
$ 245.00

SynQuest Laboratories
2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one
1 g
$ 765.00

Matrix Scientific
2-(Methylthio)pyrrolo[2,1-f]-[1,2,4]triazin-4(1H)-one
1g
$ 927.00

Crysdot
2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one 95+%
5g
$ 935.00

Crysdot
2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one 95+%
1g
$ 335.00

Chemenu
2-(methylsulfanyl)-3h,4h-pyrrolo[2,1-f][1,2,4]triazin-4-one 95%+
5g
$ 1641.00

Chemenu
2-(methylsulfanyl)-3h,4h-pyrrolo[2,1-f][1,2,4]triazin-4-one 95%+
1g
$ 666.00

Alichem
2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one
1g
$ 720.80

Total 9 raw suppliers

Chemical Property of 2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one

Chemical Property:

Melting Point:279-281 °C
Boiling Point:355.5±25.0 °C(Predicted)
PKA:-7?+-.0.20(Predicted)
PSA：75.46000
Density:1.51±0.1 g/cm3(Predicted)
LogP:0.74450
Storage Temp.:2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one

There total 2 articles about 2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1232815-49-4
2-thioxo-2,3-dihydro-1H-pyrrolo[2,1-f][1,2,4]triazin-4-one

: 74-88-4
methyl iodide

: 1232815-50-7
2-(methylsulfanyl)-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one

Guidance literature:: 2-thioxo-2,3-dihydro-1H-pyrrolo[2,1-f][1,2,4]triazin-4-one; methyl iodide; In tetrahydrofuran; at 45 ℃; for 1h;

With sodium hydrogencarbonate; In water; for 0.5h; Product distribution / selectivity;

Reference yield:

: 1232815-48-3
1-(3-benzoyl-thioureido)-1H-pyrrole-2-carboxylic acid methyl ester

: 1232815-50-7
2-(methylsulfanyl)-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 1.25 h / 85 °C

2: tetrahydrofuran / 1 h / 45 °C

With sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1021/ol2015237

Reference yield:

: 1232815-50-7
2-(methylsulfanyl)-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one

: 1232815-55-2
2-methylsulfinyl-7-phenyl-pyrrolo[2,1-f][1,2,4]triazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 4 h / 100 °C

2.1: N-Bromosuccinimide / tetrahydrofuran; methanol / 2 h / 0 - 24 °C

2.2: 3 h / 60 °C

2.3: 0.75 h

3.1: palladium diacetate; sodium carbonate; triphenylphosphine / water; N,N-dimethyl-formamide / 0.5 h / 100 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 °C

With N-Bromosuccinimide; palladium diacetate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 3.1: Suzuki coupling;
DOI:10.1021/ol2015237