N-(3-AMINOPROPYL)CYCLOHEXYLAMINE

Base Information

• Chemical Name: N-(3-AMINOPROPYL)CYCLOHEXYLAMINE
• CAS No.: 3312-60-5
• Deprecated CAS: 152725-50-3,37221-91-3,2044666-90-0,37221-91-3
• Molecular Formula: C9H20N2
• Molecular Weight: 156.271
• Hs Code.: 2921300090
• European Community (EC) Number: 222-001-7
• NSC Number: 87572
• UNII: F4XOB09FKN
• DSSTox Substance ID: DTXSID6062969
• Nikkaji Number: J47.452E
• Wikidata: Q27277640
• Mol file: 3312-60-5.mol

Synonyms:1,3-Propanediamine,N-cyclohexyl- (6CI,7CI,8CI,9CI);(Cyclohexylamino)propylamine;1-(Cyclohexylamino)-3-aminopropane;3-(Cyclohexylamino)-1-propylamine;3-Amino-1-(cyclohexylamino)propane;Laromin C252;N-(3-Aminopropyl)-N-cyclohexylamine;N-(3-Aminopropyl)cyclohexanamine;N-Cyclohexyl-1,3-diaminopropane;N-Cyclohexyl-1,3-propanediamine;N-Cyclohexyl-1,3-propylenediamine;N-Cyclohexyltrimethylenediamine;NSC 87572;Polycat 352;

Chemical Property of N-(3-AMINOPROPYL)CYCLOHEXYLAMINE

Chemical Property:

• Appearance/Colour: Pale yellow clear liquid
• Vapor Pressure: 0.0417mmHg at 25°C
• Melting Point: -17--15 °C(lit.)
• Refractive Index: n20/D 1.482(lit.)
• Boiling Point: 238.735 °C at 760 mmHg
• Flash Point: 112.298 °C
• PSA: 38.05000
• Density: 0.914 g/cm³
• LogP: 2.34870
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Air Sensitive
• Water Solubility.: 5000g/L at 20℃
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 156.162648646
• Heavy Atom Count: 11
• Complexity: 87.6

Purity/Quality:

99.9% ^*data from raw suppliers

N-(3-Aminopropyl)cyclohexylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, C
• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CCC(CC1)NCCCN
• Uses: N-(3-Aminopropyl)cyclohexylamine is a competitive inhibitor of spermine and spermidine synthases.

Technology Process of N-(3-AMINOPROPYL)CYCLOHEXYLAMINE

There total 10 articles about N-(3-AMINOPROPYL)CYCLOHEXYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N-cyclohexyl-1,3-propanediamino-N,N'-bis(trimethylmethanesulfonamide) (198712-51-5) → N-(3-aminopropyl)cyclohexylamine (3312-60-5)

Guidance literature:

With trifluorormethanesulfonic acid; methoxybenzene; In dichloromethane; at 20 ℃; for 2.5h;

DOI:10.1021/jo971455i

Reference yield:

3-cyclohexylaminopropionitrile (702-03-4) → N-(3-aminopropyl)cyclohexylamine (3312-60-5)

Guidance literature:

With ammonia; nickel; at 120 ℃; under 128714 Torr; Hydrogenation;

DOI:10.1021/ja01211a021

Reference yield:

1-Cyclohexyl-1-(β-cyanethyl)-hydrazin (3956-37-4) → N-(3-aminopropyl)cyclohexylamine (3312-60-5)

Guidance literature:

With hydrogen; nickel; In methanol;

upstream raw materials:

3-cyclohexylaminopropionitrile

1-Cyclohexyl-1-(β-cyanethyl)-hydrazin

cyclohexylamine

acrylonitrile

Downstream raw materials:

N¹-(7-chloroquinolin-4-yl)-N³-cyclohexylpropane-1,3-diamine

4H-thiochromeno[3,4-d]isoxazole-3-carboxylic acid 3-cyclohexylamino-propylamide

N-(2-Butyl-2-ethyl-5-methyl-hexa-3,4-dienyl)-N'-cyclohexyl-propane-1,3-diamine

3-Cyclohexylamino-propylguanidin

Refernces

• 1、 Rehse, Klaus,Steege, Jens. "Synthesis and antiplatelet activity of new imidazole-4-carboxylic acid derivatives". . p. 539 - 547. Retrieved 2007/10/03.
• 2、 -. "Poly-bis-triazinylimides, their preparation". . . Retrieved 2008/06/13.