5-(4-chlorophenyl)-6-(cyclobutyloxy)-3-pyridinecarboxylic acid

Base Information

Chemical Name:5-(4-chlorophenyl)-6-(cyclobutyloxy)-3-pyridinecarboxylic acid
CAS No.:1364678-51-2
Molecular Formula:C₁₆H₁₄ClNO₃
Molecular Weight:303.745
Hs Code.:
Mol file:1364678-51-2.mol

Synonyms:5-(4-chlorophenyl)-6-(cyclobutyloxy)-3-pyridinecarboxylic acid

Suppliers and Price of 5-(4-chlorophenyl)-6-(cyclobutyloxy)-3-pyridinecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 5-(4-chlorophenyl)-6-(cyclobutyloxy)-3-pyridinecarboxylic acid

Chemical Property:

Purity/Quality:: 99% ，98% ^*data from raw suppliers

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Technology Process of 5-(4-chlorophenyl)-6-(cyclobutyloxy)-3-pyridinecarboxylic acid

There total 5 articles about 5-(4-chlorophenyl)-6-(cyclobutyloxy)-3-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1364678-46-5
5-bromo-6-cyclobutyloxy-3-pyridinecarboxylic acid

: 1679-18-1
4-Chlorophenylboronic acid

: 1364678-51-2
5-(4-chlorophenyl)-6-(cyclobutyloxy)-3-pyridinecarboxylic acid

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; at 100 ℃;

Reference yield:

: 29241-62-1
5-bromo-6-chloronicotinic acid

: 1364678-51-2
5-(4-chlorophenyl)-6-(cyclobutyloxy)-3-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 20 °C

1.2: pH 2 / Cooling

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 100 °C

With potassium carbonate; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; dimethyl sulfoxide;

Reference yield:

: 41668-13-7
5-bromo-6-hydroxy-3-pyridinecarboxylic acid

: 1364678-51-2
5-(4-chlorophenyl)-6-(cyclobutyloxy)-3-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate; quinoline / 2 h / 120 °C / Inert atmosphere

2: potassium hydroxide / dimethyl sulfoxide / 0.13 h / 100 °C / Inert atmosphere; Microwave irradiation

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane; ethanol / 3.5 h / 85 °C / Inert atmosphere

With quinoline; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium hydroxide; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm4010708