3-(METHYLAMINO)AZETIDINE DIHYDROCHLORIDE

Base Information

• Chemical Name: 3-(METHYLAMINO)AZETIDINE DIHYDROCHLORIDE
• CAS No.: 136293-86-2
• Molecular Formula: C₄H₁₀N₂*2ClH
• Molecular Weight: 159.059
• Hs Code.: 2933998090
• Mol file: 136293-86-2.mol

Synonyms:3-(METHYLAMINO)AZETIDINE DIHYDROCHLORIDE;3-(MethylaMino)azetidine 2HCl;N-Methyl-3-azetidinaMine dihydrochloride

Chemical Property of 3-(METHYLAMINO)AZETIDINE DIHYDROCHLORIDE

Chemical Property:

• PSA: 24.06000
• LogP: 1.50130
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Methylazetidin-3-amineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-Methylazetidin-3-amine Dihydrochloride is a useful reagent for synthesis of novel oxazine and thiazine ring-?fused tricyclic quinolonecarboxylic acids, which are good bactericides.

Technology Process of 3-(METHYLAMINO)AZETIDINE DIHYDROCHLORIDE

There total 1 articles about 3-(METHYLAMINO)AZETIDINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(diphenylmethyl)-3-(methylamino)azetidine (69159-49-5) → 3-(methylamino)azetidine dihydrochloride (133891-77-7,136293-86-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1248/cpb.41.126

Reference yield:

1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-6,7-difluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid + 3-(methylamino)azetidine dihydrochloride (133891-77-7,136293-86-2) → 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-6-fluoro-8-methyl-7-((3-methylamino)azetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:

With lithium hydroxide monohydrate; lithium chloride; N,N,N',N'-tetramethylguanidine; In dimethyl sulfoxide; at 20 ℃; for 120h;

Reference yield:

ethyl 1-(2-acetoxymethyl-5-amino-4-fluorophenyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate + 3-(methylamino)azetidine dihydrochloride (133891-77-7,136293-86-2) → ethyl 1-(2-acetoxymethyl-5-amino-4-fluorophenyl)-6-fluoro-7-[3-(methylamino)azetidin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylate

Guidance literature:

With N,N,N',N'-tetramethylguanidine; In acetonitrile; at 35 ℃;

upstream raw materials:

1-(diphenylmethyl)-3-(methylamino)azetidine

Refernces