5-Bromo-1-ethylbenzoimidazole

Base Information

• Chemical Name: 5-Bromo-1-ethylbenzoimidazole
• CAS No.: 23073-51-0
• Molecular Formula: C₉H₉BrN₂
• Molecular Weight: 225.088
• Hs Code.: 2933990090
• Mol file: 23073-51-0.mol

Synonyms:5-Bromo-1-ethylbenzoimidazole;5-Bromo-1-ethyl-1H-benzo[d]imidazole

Chemical Property of 5-Bromo-1-ethylbenzoimidazole

Chemical Property:

• PSA: 17.82000
• LogP: 2.81870

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-1-ethylbenzoimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-1-ethylbenzoimidazole

There total 6 articles about 5-Bromo-1-ethylbenzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-bromo-N1-ethylbenzene-1,2-diamine + trimethyl orthoformate (149-73-5) → 5-bromo-1-ethyl-1H-benzimidazole (23073-51-0)

Guidance literature:

In methanol; at 70 ℃; for 16h;

Reference yield:

ethyl bromide (74-96-4) + 5-bromo-1H-benzo[d]imidazole (4887-88-1) → 5-bromo-1-ethyl-1H-benzimidazole (23073-51-0) + 6-bromo-1-ethyl-1H-benzo[d]imidazole (813449-00-2)

Guidance literature:

With sodium hydroxide; In water; acetonitrile; at 20 ℃; for 24h; Overall yield = 75 percent; Overall yield = 0.427 g; Inert atmosphere;

DOI:10.1021/acs.organomet.1c00019

Reference yield:

(4-bromo-2-nitrophenyl)ethylamine (56136-82-4) → 5-bromo-1-ethyl-1H-benzimidazole (23073-51-0)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; acetic acid / ethanol / 16 h / 70 °C / Inert atmosphere

2: methanol / 16 h / 70 °C

With iron; acetic acid; In methanol; ethanol;

upstream raw materials:

4-Bromo-2-nitroaniline

ethyl bromide

5-bromo-1H-benzo[d]imidazole

(4-bromo-2-nitrophenyl)ethylamine

Refernces

• 1、 -. "INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES". . . Retrieved 2021/12/28.