Ethyl 5-broMo-6-Methylpicolinate

Base Information

• Chemical Name: Ethyl 5-broMo-6-Methylpicolinate
• CAS No.: 1122090-71-4
• Molecular Formula: C9H10BrNO2
• Molecular Weight: 244.0852
• Hs Code.: 2933399090
• Mol file: 1122090-71-4.mol

Synonyms:Ethyl 5-broMo-6-Methylpicolinate;ETHYL 5-BROMO-6-METHYLPICOLINATE/5-bromo-6-methyl-pyridine-2-carboxylic acid ethyl ester;5-Bromo-6-methylpyridine-2-carboxylic acid ethyl ester

Chemical Property of Ethyl 5-broMo-6-Methylpicolinate

Chemical Property:

• PSA: 39.19000
• LogP: 2.32920
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-Bromo-6-methylpicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 5-broMo-6-Methylpicolinate

There total 4 articles about Ethyl 5-broMo-6-Methylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + 5-bromo-6-methylpyridine-2-carbonitrile (1173897-86-3) → ethyl 5-bromo-6-methylpyridine-2-carboxylate (1122090-71-4)

Guidance literature:

With borane-THF; Reflux;

Reference yield:

3-bromo-2-methyl-6-vinylpyridine (1122090-67-8) → ethyl 5-bromo-6-methylpyridine-2-carboxylate (1122090-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium permanganate / water; acetone / 72 h / 20 °C

2: sulfuric acid / 18 h / 70 °C / Inert atmosphere

With potassium permanganate; sulfuric acid; In water; acetone;

DOI:10.1021/jm4014696

Reference yield:

ethanol (64-17-5) + 3-bromo-2-methyl-6-pyridinecarboxylic acid (137778-20-2) → ethyl 5-bromo-6-methylpyridine-2-carboxylate (1122090-71-4)

Guidance literature:

With sulfuric acid; at 70 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm4014696

upstream raw materials:

ethanol

5-bromo-6-methylpyridine-2-carbonitrile

3-bromo-2-methyl-6-vinylpyridine

3-bromo-2-methyl-6-pyridinecarboxylic acid