3-fluoro-3-Pyrrolidinecarboxylic acid

Base Information

• Chemical Name: 3-fluoro-3-Pyrrolidinecarboxylic acid
• CAS No.: 1228634-93-2
• Molecular Formula: C5H8FNO2
• Molecular Weight: 133.122
• Mol file: 1228634-93-2.mol

Synonyms:3-fluoro-3-Pyrrolidinecarboxylic acid

Chemical Property of 3-fluoro-3-Pyrrolidinecarboxylic acid

Chemical Property:

• Boiling Point: 238℃
• Flash Point: 98℃
• PSA: 49.33000
• Density: 1.31
• LogP: 0.10140

Purity/Quality:

99%, ^*data from raw suppliers

3-Fluoropyrrolidine-3-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-fluoro-3-Pyrrolidinecarboxylic acid

There total 2 articles about 3-fluoro-3-Pyrrolidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-benzyl-3-fluoropyrrolidine-3-carboxylic acid (1279669-56-5) → 3-fluoropyrrolidine-3-carboxylic acid (1228634-93-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 10h; under 15201 Torr;

DOI:10.1016/j.tetlet.2011.01.070

Reference yield:

methyl 1-benzyl-3-fluoropyrrolidine-3-carboxylate (1279669-60-1) → 3-fluoropyrrolidine-3-carboxylic acid (1228634-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 7 h / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 20 °C / 15201 Torr

With palladium 10% on activated carbon; hydrogen; sodium hydroxide; In methanol; water;

DOI:10.1016/j.tetlet.2011.01.070

Reference yield: 90.0%

3-fluoropyrrolidine-3-carboxylic acid (1228634-93-2) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → N-Fmoc-3-fluoro-β-proline (1279669-61-2)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2011.01.070

upstream raw materials:

methyl 1-benzyl-3-fluoropyrrolidine-3-carboxylate

1-benzyl-3-fluoropyrrolidine-3-carboxylic acid

Downstream raw materials:

(±)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid

N-Fmoc-3-fluoro-β-proline

1-[(benzyloxy)carbonyl]-3-fluoropyrrolidine-3-carboxylic acid

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