Chemical Property of FMoc-N-Me-Cys(Trt)-OH
Chemical Property:
- Melting Point:234-239°C
- Boiling Point:746.0±60.0 °C(Predicted)
- PKA:3.72±0.10(Predicted)
- PSA:92.14000
- Density:1.260±0.06 g/cm3(Predicted)
- LogP:8.04580
- Storage Temp.:2-8°C
- Purity/Quality:
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≥98%,≥99%, *data from raw suppliers
Fmoc-N-Me-L-Cys(Trt)-OH *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Uses
Fmoc-N-Me-L-Cys(Trt)-OH (CAS# 944797-51-7) is an fmoc- and trityl-protected derivative of L-cysteine (C995000) used as a building block for peptides or peptide fragments, such as the solid-phase synthesis of Triostin A. Fmoc-N-Me-Cys(Trt)-OH is a Fmoc-protected derivative of N-methyl cysteine used as a building block to prepare peptide thioesters under acidic conditions. The residue attached to the amino group of N-methylcysteine can migrate to the cysteinyl thiol group, resulting in the formation of a peptide thioester. The introduction of this Fmoc-protected derivative is best achieved using HATU as a coupling reagent in the presence of DIPEA (N, N-Diisopropylethylamine). It can also be used to prepare Fmoc-N-Me-Cys(Trt)-OAllyl intermediate for the solid-phase synthesis of dithiol Triostin A.