Technology Process of N-[2-[4-[[[2-[(HYDROXYAMINO)CARBONYL]-4,6-DIMETHYLPHENYL](PHENYLMETHYL)AMINO]SULFONYL]PHENOXY]ETHYL]-2-BENZOFURANCARBOXAMIDE
There total 4 articles about N-[2-[4-[[[2-[(HYDROXYAMINO)CARBONYL]-4,6-DIMETHYLPHENYL](PHENYLMETHYL)AMINO]SULFONYL]PHENOXY]ETHYL]-2-BENZOFURANCARBOXAMIDE which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-[[(4-{2-[(1-benzofuran-2-ylcarbonyl)amino]ethoxy}phenyl)sulfonyl](benzyl)amino]-3,5-dimethylbenzoic acid;
With
benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
N,N-dimethyl-formamide;
for 1h;
With
hydroxylamine hydrochloride; triethylamine;
In
N,N-dimethyl-formamide;
Further stages.;
DOI:10.1021/ja001547g
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 43 percent / HOBt; EDC; NMM / dimethylformamide / 4.17 h / 0 - 20 °C
2.1: NaH / dimethylformamide / 0.5 h / 0 °C
2.2: 58 percent / dimethylformamide / 0 - 20 °C
3.1: HOBt; EDC / dimethylformamide / 1 h
3.2: 58 percent / Et3N; hydroxylamine hydrochloride / dimethylformamide
With
4-methyl-morpholine; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
N,N-dimethyl-formamide;
DOI:10.1021/ja001547g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: NaH / dimethylformamide / 0.5 h / 0 °C
1.2: 58 percent / dimethylformamide / 0 - 20 °C
2.1: HOBt; EDC / dimethylformamide / 1 h
2.2: 58 percent / Et3N; hydroxylamine hydrochloride / dimethylformamide
With
sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
N,N-dimethyl-formamide;
DOI:10.1021/ja001547g
