1,6,7,8-Indolizinetetrol, octahydro-, 1,6,7-tribenzoate 8-methanesulfonate, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

Base Information

Chemical Name:1,6,7,8-Indolizinetetrol, octahydro-, 1,6,7-tribenzoate 8-methanesulfonate, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-
CAS No.:171925-22-7
Molecular Formula:C₃₀H₂₉NO₉S
Molecular Weight:579.628
Hs Code.:
Mol file:171925-22-7.mol

Synonyms:1,6,7,8-Indolizinetetrol, octahydro-, 1,6,7-tribenzoate 8-methanesulfonate, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

Suppliers and Price of 1,6,7,8-Indolizinetetrol, octahydro-, 1,6,7-tribenzoate 8-methanesulfonate, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,6,7,8-Indolizinetetrol, octahydro-, 1,6,7-tribenzoate 8-methanesulfonate, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

Chemical Property:

PSA：133.89000
LogP:4.11460

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,6,7,8-Indolizinetetrol, octahydro-, 1,6,7-tribenzoate 8-methanesulfonate, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

There total 1 articles about 1,6,7,8-Indolizinetetrol, octahydro-, 1,6,7-tribenzoate 8-methanesulfonate, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79831-76-8
(1S,6S,7R,8R,8aR)-2,6,7,8-tetrahydroxy-indolizidine

: 98-88-4
benzoyl chloride

: 124-63-0
methanesulfonyl chloride

: 171925-22-7
1,6,7-tri-O-benzoyl-8-O-methanesulfonylcastanospermine

: 171925-23-8
1,6,8-tri-O-benzoyl-7-O-methanesulfonylcastanospermine

Guidance literature:: With pyridine; di(n-butyl)tin oxide; Yield given. Multistep reaction. Yields of byproduct given; 1.) MePh, reflux, 2 h, 2.) MePh, -70 deg C to room t., 3.) room t.;
DOI:10.1016/0040-4020(95)00803-G

Reference yield:

: 171925-22-7
1,6,7-tri-O-benzoyl-8-O-methanesulfonylcastanospermine

: 171925-24-9
8-azido-1,6,7-tri-O-benzoyl-8-deoxycastanospermine

: 171925-25-0
8-azido-1,2,7-tri-O-benzoyl-1(R),2(S),7(S),8(R)8a(R)-trihydroxyoctahydroindolizidine

Guidance literature:: With sodium azide; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 80 ℃; for 2h; Yield given. Yields of byproduct given;
DOI:10.1016/0040-4020(95)00803-G

Reference yield:

: 171925-22-7
1,6,7-tri-O-benzoyl-8-O-methanesulfonylcastanospermine

: C₃₁H₃₀N₂O₇

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaN₃, 2.) H₂ / 2.) 20percent Pd(OH)2/C / 1.) HMPT, 80 deg C, 2 h, 2.) EtOAc, EtOH, 24 h

2: pyridine / 3 h / Ambient temperature

With pyridine; sodium azide; hydrogen; palladium dihydroxide;
DOI:10.1016/0040-4020(95)00803-G