2H-Pyrano(3,2-c)quinoline-3-carboxylic acid, 5-(dimethylamino)-2-oxo-, methyl ester

Base Information

Chemical Name:2H-Pyrano(3,2-c)quinoline-3-carboxylic acid, 5-(dimethylamino)-2-oxo-, methyl ester
CAS No.:172753-40-1
Molecular Formula:C₁₆H₁₄N₂O₄
Molecular Weight:298.298
Hs Code.:
DSSTox Substance ID:DTXSID30169391
Wikidata:Q83039067

Synonyms:Methyl 5-(dimethylamino)-2-oxo-2H-pyrano(3,2-c)quinoline-3-carboxylate;2H-Pyrano(3,2-c)quinoline-3-carboxylic acid, 5-(dimethylamino)-2-oxo-, methyl ester;172753-40-1;3-Methylcarbonyl-5-dimethylaminopyrano(3,2-c)quinolin-2-one;DTXSID30169391;LS-127532

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-Pyrano(3,2-c)quinoline-3-carboxylic acid, 5-(dimethylamino)-2-oxo-, methyl ester

Chemical Property:

Vapor Pressure:3.32E-11mmHg at 25°C
Boiling Point:527.3°C at 760 mmHg
Flash Point:272.7°C
Density:1.368g/cm³
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:298.09535693
Heavy Atom Count:22
Complexity:502

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C1=NC2=CC=CC=C2C3=C1C=C(C(=O)O3)C(=O)OC

Technology Process of 2H-Pyrano(3,2-c)quinoline-3-carboxylic acid, 5-(dimethylamino)-2-oxo-, methyl ester

There total 3 articles about 2H-Pyrano(3,2-c)quinoline-3-carboxylic acid, 5-(dimethylamino)-2-oxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 67-56-1
methanol

: 172753-44-5
2-dimethylamino-3-<(2,2-dimethyl-4,6-dioxo-1,3-dioxacyclohexane-5-ylidene)methyl>-4-chloroquinoline

: 172753-40-1
2-methoxycarbonyl-5-dimethylaminopyrano<3,2-c>quinolin-2-one

Guidance literature:: With triethylamine; Heating;
DOI:10.1007/BF02226521

Reference yield: 62.0%

: 67-56-1
methanol

: 2033-24-1
cycl-isopropylidene malonate

: α-cyano-β-(2-dimethylamino-4-chloroquinoline-3-yl)acrylic acid nitrile

: 172753-40-1
2-methoxycarbonyl-5-dimethylaminopyrano<3,2-c>quinolin-2-one

Guidance literature:: With triethylamine; for 4h; Heating;
DOI:10.1007/BF02226521

Reference yield:

: 159112-46-6
4-chloro-3-formyl-2-dimethylaminoquinoline

: 172753-40-1
2-methoxycarbonyl-5-dimethylaminopyrano<3,2-c>quinolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / Et₃N / CHCl₃ / 2.5 h / 20 °C

2: 64 percent / Et₃N / Heating

With triethylamine; In chloroform;
DOI:10.1007/BF02226521