2-CYANO-3-NITROQUINOLINE

Base Information

• Chemical Name: 2-CYANO-3-NITROQUINOLINE
• CAS No.: 102170-61-6
• Molecular Formula: C₁₀H₅N₃O₂
• Molecular Weight: 199.169
• Mol file: 102170-61-6.mol

Synonyms:2-CYANO-3-NITROQUINOLINE

Chemical Property of 2-CYANO-3-NITROQUINOLINE

Chemical Property:

• Vapor Pressure: 4.84E-07mmHg at 25°C
• Boiling Point: 413.3°C at 760 mmHg
• Flash Point: 203.8°C
• PSA: 82.50000
• Density: 1.43g/cm³
• LogP: 2.53788

Purity/Quality:

95% ^*data from raw suppliers

2-CYANO-3-NITROQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CYANO-3-NITROQUINOLINE

There total 4 articles about 2-CYANO-3-NITROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-nitroquinoline N-oxide (7433-86-5) + trimethylsilyl cyanide (7677-24-9) → 3-nitroquinoline-2-carbonitrile (102170-61-6)

Guidance literature:

In neat (no solvent); at 130 ℃; for 1h; regioselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1002/adsc.201901103

Reference yield:

Quinoline N-oxide (1613-37-2) → 3-nitroquinoline-2-carbonitrile (102170-61-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tert.-butylnitrite / acetonitrile / 24 h / 100 °C / Inert atmosphere

2: neat (no solvent) / 1 h / 130 °C / Sealed tube; Inert atmosphere

With tert.-butylnitrite; In acetonitrile;

DOI:10.1002/adsc.201901103

Reference yield:

quinoline (91-22-5) → 3-nitroquinoline-2-carbonitrile (102170-61-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 15 h / 0 - 20 °C

2: tert.-butylnitrite / acetonitrile / 24 h / 100 °C / Inert atmosphere

3: neat (no solvent) / 1 h / 130 °C / Sealed tube; Inert atmosphere

With tert.-butylnitrite; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;

DOI:10.1002/adsc.201901103

upstream raw materials:

Quinoline N-oxide

3-nitroquinoline N-oxide

trimethylsilyl cyanide

quinoline

Refernces