7433-86-5

Basic information

• Product Name: 3-Nitro-quinoline 1-oxide
• Synonyms: 3-Nitro-quinoline 1-oxide;3-Nitroquinoline 1-oxide
• CAS NO: 7433-86-5
• Molecular Formula: C₉H₆N₂O₃
• Molecular Weight: 190.1555
• Mol File: 7433-86-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 400.9°Cat760mmHg
• Flash Point: 196.3°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 2.83E-06mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: 3-Nitro-quinoline 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Nitro-quinoline 1-oxide(7433-86-5)
• EPA Substance Registry System: 3-Nitro-quinoline 1-oxide(7433-86-5)

Safety Data

• Hazardous Substances Data: 7433-86-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H6N2O3/c12-10-6-8(11(13)14)5-7-3-1-2-4-9(7)10/h1-6H

Upstream product

• 1613-37-2 Quinoline N-oxide 
• 98-88-4 benzoyl chloride 
• 75-36-5 acetyl chloride 
• 540-80-7 tert.-butylnitrite 
• 67-66-3 chloroform 
• 17576-53-3 3-nitroquinoline 
• 91-22-5 quinoline 

Downstream Products

• 131459-07-9 1-benzoyloxy-3,6-dinitro-1H-quinolin-2-one 
• 102079-68-5 3,6-bis-acetylamino-1-benzoyloxy-1H-quinolin-2-one 
• 102170-61-6 3-nitroquinoline-2-carbonitrile 
• 580-17-6 3-aminoquinoline 
• 1344663-94-0 3-nitro-2-phenylquinoline-1-oxide 
• 78105-39-2 2,3-diaminoquinoline 
• 52448-21-2 3-phenyl-3H-oxazolo[4,5-b]quinolin-2-one 
• 103029-75-0 3-Nitro-chinolin-2-ol 
• 17576-53-3 3-nitroquinoline 
• 62141-03-1 1-oxy-quinolin-3-ylamine 

Relevant articles and documents

Photochemical reactions on heterocyclic compounds. I. Nitration of quinoline 1-oxide with nitrosyl chloride and n-butyl nitrite.

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Regioselective Cyanation of Six-Membered N-Heteroaromatic Compounds Under Metal-, Activator-, Base- and Solvent-Free Conditions

A regioselective cyanation of heteroaromatic N-oxides with trimethylsilyl cyanide has been developed to obtain 2-substituted N-heteroaromatic nitrile without the requirement of any external activator-, metal-, base-, and solvent. The present protocol is a straightforward, one-pot heteroaromatic C?H cyanation process, and proceeds smoothly in conventional heating but also under microwave irradiation with shorter reaction times. This approach now allows access to a broad class of quinoline N-oxides and other heteroarene N-oxides with high to good yields and can also be scaled up to obtain gram quantities. Further application of this process was observed and utilized in late-stage cyanation of the anti-malarial drug quinine as well as transformation of the 2-cyanoazines to a series of biologically important molecules. Based on the experimental observations, a plausible mechanism has also been proposed highlighting the dual role of trimethylsilyl cyanide as a nitrile source and as an activating agent. (Figure presented.).

Nitro-substituted quinoline nitrogen oxide derivative and preparation method thereof

The invention relates to a nitro-substituted quinoline nitrogen oxide derivative and a preparation method thereof. A structural formula of the nitro-substituted quinoline nitrogen oxide derivative is shown in a specification, wherein R1-R4 can be respectively and independently selected from hydrogen, halogen, alkyl group, alkyloxy group and phenyl group. The structure of the nitro-substituted quinoline nitrogen oxide derivative has a nitro group, can be taken as an organic synthesis intermediate, and has important application values in the fields of natural products, medical production and organic synthesis; and the compound has good application prospect for preparing antineoplastic medicines.

Condensed heterocycles; XI. Synthesis of 1,2,5-thia(selena)diazolo[3,4-b]quinolines and 1,2,5-thia(selena)diazolo[3,4-h]quinolines

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