2-[4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid

Base Information

• Chemical Name: 2-[4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid
• CAS No.: 1195941-38-8
• Molecular Formula: C27H27NO5
• Molecular Weight: 445.515
• Mol file: 1195941-38-8.mol

Synonyms:2-[4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid

Chemical Property of 2-[4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid

Chemical Property:

• Boiling Point: 659.0±55.0 °C(Predicted)
• PSA: 84.86000
• Density: 1.28±0.1 g/cm3(Predicted)
• LogP: 4.36800

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid

There total 4 articles about 2-[4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid methyl ester (1195941-37-7) → 2-{4-methoxy-3-[2-(3-methylphenyl)ethoxy]benzamido}-2,3-dihydro-1H-indene-2-carboxylic acid (1195941-38-8)

Guidance literature:

2-[4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid methyl ester; With water; lithium hydroxide; In 1,4-dioxane; at 60 ℃; for 0.5h;

With hydrogenchloride; In 1,4-dioxane; water; ethyl acetate;

Reference yield:

4-methoxy-3-(2-m-tolyl-ethoxy)-benzoic acid (1195944-88-7) → 2-{4-methoxy-3-[2-(3-methylphenyl)ethoxy]benzamido}-2,3-dihydro-1H-indene-2-carboxylic acid (1195941-38-8)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 0.33 h / 60 °C

2: sodium hydrogencarbonate / dichloromethane; water; ethyl acetate / 0.5 h / 20 °C

3: water; lithium hydroxide / 1,4-dioxane / 0.5 h / 60 °C

With thionyl chloride; water; sodium hydrogencarbonate; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; ethyl acetate;

Reference yield:

4-methoxy-3-(2-m-tolyl-ethoxy)-benzoyl chloride (1195945-75-5) → 2-{4-methoxy-3-[2-(3-methylphenyl)ethoxy]benzamido}-2,3-dihydro-1H-indene-2-carboxylic acid (1195941-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane; water; ethyl acetate / 0.5 h / 20 °C

2: water; lithium hydroxide / 1,4-dioxane / 0.5 h / 60 °C

With water; sodium hydrogencarbonate; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; ethyl acetate;

upstream raw materials:

2-[4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid methyl ester

4-methoxy-3-(2-m-tolyl-ethoxy)-benzoyl chloride

4-methoxy-3-(2-m-tolyl-ethoxy)-benzoic acid

2-amino-indane-2-carboxylic acid methyl ester hydrochloride

Downstream raw materials:

2-[4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid amide