2-AMINO-INDAN-2-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: 2-AMINO-INDAN-2-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
• CAS No.: 199330-64-8
• Molecular Formula: C₁₁H₁₃NO₂*ClH
• Molecular Weight: 227.691
• Hs Code.: 2922499990
• Mol file: 199330-64-8.mol

Synonyms:2-AMINO-INDAN-2-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;2-AMINO-INDANE-2-CARBOXYLIC ACID METHYL ESTER HCL;2-Aminoindan-2-carboxylic acid methyl ester HCl;1H-Indene-2-carboxylic acid, 2-aMino-2,3-dihydro-, Methyl ester, hydrochloride;H-Aic-OMe.HCl;1H-Indene-2-carboxylic acid, 2-amino-2,3-dihydro-, methyl ester, hydrochloride (1:1);Methyl 2-Amino-indan-2-carboxylate HCl;Methyl 2-amino-2,3-dihydro-1H-indene-2-carbox...

Chemical Property of 2-AMINO-INDAN-2-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE

Chemical Property:

• PSA: 52.32000
• LogP: 2.15800
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-Amino-2,3-dihydro-1H-indene-2-carboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-INDAN-2-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE

There total 3 articles about 2-AMINO-INDAN-2-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-indanone (615-13-4) → 2-amino-indane-2-carboxylic acid methyl ester hydrochloride (199330-64-8)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium carbonate / aq. ethanol / 55 - 60 °C

2: aq. NaOH / 72 h / Heating

3: HCl / 4 h / Heating

With ammonium carbonate; hydrogenchloride; sodium hydroxide; In ethanol;

DOI:10.1021/ja962905b

Reference yield:

methanol (67-56-1) + 2-amino-2,3-dihydro-1H-indene-2-carboxylic acid (27473-62-7) → 2-amino-indane-2-carboxylic acid methyl ester hydrochloride (199330-64-8)

Guidance literature:

With hydrogenchloride; for 4h; Heating;

DOI:10.1021/ja962905b

Reference yield:

(+/-)spiro[imidazolidine-4,2'-indane]-2,5-dione (27473-61-6) → 2-amino-indane-2-carboxylic acid methyl ester hydrochloride (199330-64-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / 72 h / Heating

2: HCl / 4 h / Heating

With hydrogenchloride; sodium hydroxide;

DOI:10.1021/ja962905b

upstream raw materials:

methanol

2-amino-2,3-dihydro-1H-indene-2-carboxylic acid

2-indanone

(+/-)spiro[imidazolidine-4,2'-indane]-2,5-dione

Downstream raw materials:

2-[4-methoxy-3-(2-m-tolyl-ethanesulfonyl)-benzoylamino]-indane-2-carboxylic acid

2-[4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid amide

2-[4-methoxy-3-(2-m-tolyl-ethylsulfanyl)-benzoylamino]-indane-2-carboxylic acid

2-{4-methoxy-3-[2-(3-methylphenyl)ethoxy]benzamido}-2,3-dihydro-1H-indene-2-carboxylic acid

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