4-MethoxycarbonylMethyl-piperazine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-MethoxycarbonylMethyl-piperazine-1-carboxylic acid tert-butyl ester
• CAS No.: 731810-20-1
• Molecular Formula: C₁₂H₂₂N₂O₄
• Molecular Weight: 258.318
• Hs Code.: 2933599090
• Mol file: 731810-20-1.mol

Synonyms:4-MethoxycarbonylMethyl-piperazine-1-carboxylic acid tert-butyl ester;tert-Butyl 4-(2-Methoxy-2-oxoethyl)piperazine-1-carboxylate

Chemical Property of 4-MethoxycarbonylMethyl-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 330.4±37.0 °C(Predicted)
• PKA: 4.75±0.10(Predicted)
• PSA: 59.08000
• Density: 1.107±0.06 g/cm3(Predicted)
• LogP: 0.58790

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl4-(2-Methoxy-2-oxoethyl)piperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-MethoxycarbonylMethyl-piperazine-1-carboxylic acid tert-butyl ester

There total 5 articles about 4-MethoxycarbonylMethyl-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

bromoacetic acid methyl ester (96-32-2) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate (731810-20-1)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 4h;

Reference yield: 59.0%

tert-butyl 4-chloropiperazine-1-carboxylate (1193466-76-0) + ketene t-butyldimethylsilyl methyl acetal (77086-38-5) → tert-butyl 4-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate (731810-20-1)

Guidance literature:

With [2,2]bipyridinyl; copper(l) iodide; In acetonitrile; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol302331k

Reference yield:

sodium hydrogencarbonate (144-55-8) + bromoacetic acid methyl ester (96-32-2) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate (731810-20-1)

Guidance literature:

With triethanolamine; In acetonitrile;

upstream raw materials:

bromoacetic acid methyl ester

1-t-Butoxycarbonylpiperazine

sodium hydrogencarbonate

tert-butyl 4-chloropiperazine-1-carboxylate

Downstream raw materials:

N-(2-(dimethylamino)ethyl)piperazine

methyl 2-(piperazin-1-yl)ethanoate hydrochloride

methyl 2-(piperazin-1-yl)acetate