DIM-C-pPhOCH3

Base Information

• Chemical Name: DIM-C-pPhOCH3
• CAS No.: 33985-68-1
• Molecular Formula: C24H20N2O
• Molecular Weight: 352.436
• ChEMBL ID: CHEMBL2376692
• DSSTox Substance ID: DTXSID20463916
• Nikkaji Number: J742.728J
• Wikidata: Q82289015
• Mol file: 33985-68-1.mol

Synonyms:DIM-C-pPhOCH3;33985-68-1;3,3'-((4-Methoxyphenyl)methylene)bis(1H-indole);C-DIM5;3-[1H-indol-3-yl-(4-methoxyphenyl)methyl]-1H-indole;DIM-C-pPhOCH3(C-DIM5);SCHEMBL2546810;CHEMBL2376692;DTXSID20463916;BCP28953;AKOS027393741;di(indol-3-yl)-p-methoxyphenylmethane;DIM-C-pPhOCH3, >=98% (HPLC);BS-50939;HY-111492;CS-0042246;E76636;DIM C pPhOCH3;DIM-C-pPhOMe;DIM C pPhOMe;1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane

Chemical Property of DIM-C-pPhOCH3

Chemical Property:

• Melting Point: 187-189 °C
• Boiling Point: 592.7±50.0 °C(Predicted)
• PKA: 16.63±0.30(Predicted)
• PSA: 40.81000
• Density: 1.251±0.06 g/cm3(Predicted)
• LogP: 5.83800
• Storage Temp.: 2-8°C
• Solubility.: DMSO: ≥30mg/mL
• XLogP3: 5.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 352.157563266
• Heavy Atom Count: 27
• Complexity: 457

Purity/Quality:

97% ^*data from raw suppliers

[Bis(1H-indol-3-yl)(4-methoxyphenyl)]methane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CNC3=CC=CC=C32)C4=CNC5=CC=CC=C54
• Uses: [Bis(1H-indol-3-yl)(4-methoxyphenyl)]methane, is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.

Technology Process of DIM-C-pPhOCH3

There total 37 articles about DIM-C-pPhOCH3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

indole (120-72-9) + 4-methoxy-benzaldehyde (123-11-5) → 3-[1H-indol-3-yl(4-methoxyphenyl)methyl]-1H-indole (33985-68-1)

Guidance literature:

With iodine; In acetonitrile; at 20 ℃;

DOI:10.1016/S0040-4039(03)00032-7

Reference yield: 97.0%

indole (120-72-9) + p-Anisaldehyde dimethyl acetal (2186-92-7) → 3-[1H-indol-3-yl(4-methoxyphenyl)methyl]-1H-indole (33985-68-1)

Guidance literature:

With Nanoporous Aluminosilicate AS-⁽¹³⁾; In acetonitrile; at 60 ℃; for 0.5h;

DOI:10.1039/c1gc15669a

Reference yield: 96.0%

indole (120-72-9) + 4-methoxy-benzaldehyde (123-11-5) → 3-[1H-indol-3-yl(4-methoxyphenyl)methyl]-1H-indole (33985-68-1)

Guidance literature:

In neat (no solvent); at 60 ℃; for 0.3h;

DOI:10.1080/24701556.2021.1980039

upstream raw materials:

indole

p-methoxybenzylidene-phenylamine

4-methoxy-benzaldehyde

(E)-N-(4-methoxybenzylidene)4-methylaniline

Downstream raw materials:

indole

12-(4-methoxyphenyl)-6-(4-methylphenyl)-5,7-dihydroindolo[2,3-b]carbazole

12-(4-methoxyphenyl)-6-phenyl-5,7-dihydroindolo[2,3-b]carbazole

3-[(1H-indol-3-yl)(4-methoxy-phenyl)methylene]-3H-indole