3,5-DIMETHYL-FURAN-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 3,5-DIMETHYL-FURAN-2-CARBOXYLIC ACID
• CAS No.: 34297-68-2
• Molecular Formula: C7H8O3
• Molecular Weight: 140.13662
• Mol file: 34297-68-2.mol

Synonyms:3,5-DIMETHYL-FURAN-2-CARBOXYLIC ACID

Chemical Property of 3,5-DIMETHYL-FURAN-2-CARBOXYLIC ACID

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

3,5-dimethylfuran-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DIMETHYL-FURAN-2-CARBOXYLIC ACID

There total 8 articles about 3,5-DIMETHYL-FURAN-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

3-methylfuran-2-carboxylic acid (4412-96-8) + methyl iodide (74-88-4) → 3,5-dimethyl-2-furancarboxylic acid (34297-68-2)

Guidance literature:

3-methylfuran-2-carboxylic acid; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.25h;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/acs.jmedchem.6b00085

Reference yield:

3-methylfuran-2-carboxylic acid (4412-96-8) → 3,5-dimethyl-2-furancarboxylic acid (34297-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium di-isopropyl amide (2 equiv.) / tetrahydrofuran; hexane / 0.25 h / -78 °C

2: 0.38 g / tetrahydrofuran; hexane / -78 °C

With lithium diisopropyl amide; In tetrahydrofuran; hexane;

DOI:10.1039/P19810001125

Reference yield:

methyl 3-methylfuran-2-carboxylate (6141-57-7) → 3,5-dimethyl-2-furancarboxylic acid (34297-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hydroxide; water / methanol; tetrahydrofuran / 10 h / 25 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -78 °C

2.2: -78 - 20 °C

With water; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol;

DOI:10.1021/acs.jmedchem.6b00085

upstream raw materials:

3,5-dimethyl-furan-2-carbaldehyde

methyl iodide

3-methylfuran-2-carboxylic acid

2,4-dimethylfuran

Refernces

• 1、 Crowley, Vincent M.,Khandelwal, Anuj,Mishra, Sanket,Stothert, Andrew R.,Huard, Dustin J. E.,Zhao, Jinbo,Muth, Aaron,Duerfeldt, Adam S.,Kizziah, James L.,Lieberman, Raquel L.,Dickey, Chad A.,Blagg, Brian S. J.. "Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold". . p. 3471 - 3488. Retrieved 2016/05/19.