{2-[(4-methoxyphenoxy)methyl]-4-(methylethylidene)-5-oxo-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate

Base Information

Chemical Name:{2-[(4-methoxyphenoxy)methyl]-4-(methylethylidene)-5-oxo-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate
CAS No.:932711-37-0
Molecular Formula:C₃₃H₂₈O₆
Molecular Weight:520.582
Hs Code.:

Synonyms:{2-[(4-methoxyphenoxy)methyl]-4-(methylethylidene)-5-oxo-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate

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Chemical Property of {2-[(4-methoxyphenoxy)methyl]-4-(methylethylidene)-5-oxo-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate

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Technology Process of {2-[(4-methoxyphenoxy)methyl]-4-(methylethylidene)-5-oxo-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate

There total 7 articles about {2-[(4-methoxyphenoxy)methyl]-4-(methylethylidene)-5-oxo-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134856-58-9
1-iodo-4-(trimethylsilylethynyl)benzene

: 932711-37-0
{2-[(4-methoxyphenoxy)methyl]-4-(methylethylidene)-5-oxo-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / piperidine / PdCl₂(PPh₃)2; CuI / tetrahydrofuran / 3 h

2: tetra-n-butylammonium fluoride / tetrahydrofuran / 0.25 h

3: 440 mg / dimethylaminopyridine; bis(2-oxo-3-oxazolidinyl)phosphinic acid chloride / CH₂Cl₂ / 1 h

With piperidine; dmap; tetrabutyl ammonium fluoride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane; 1: Sonogashira coupling;
DOI:10.1021/jm061289j

Reference yield:

: 75867-39-9
4-trimethylsilylethynyl aniline

: 932711-37-0
{2-[(4-methoxyphenoxy)methyl]-4-(methylethylidene)-5-oxo-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: NaNO₂; HCl; KI

2: 65 percent / piperidine / PdCl₂(PPh₃)2; CuI / tetrahydrofuran / 3 h

3: tetra-n-butylammonium fluoride / tetrahydrofuran / 0.25 h

4: 440 mg / dimethylaminopyridine; bis(2-oxo-3-oxazolidinyl)phosphinic acid chloride / CH₂Cl₂ / 1 h

With piperidine; hydrogenchloride; dmap; tetrabutyl ammonium fluoride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium iodide; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane; 2: Sonogashira coupling;
DOI:10.1021/jm061289j

Reference yield:

: 932711-31-4
5-[(4-methoxyphenoxy)methyl]-3-(methylethylidene)-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one

: 932711-37-0
{2-[(4-methoxyphenoxy)methyl]-4-(methylethylidene)-5-oxo-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / BCl₃ / CH₂Cl₂ / 2 h / -78 °C

2: 440 mg / dimethylaminopyridine; bis(2-oxo-3-oxazolidinyl)phosphinic acid chloride / CH₂Cl₂ / 1 h

With dmap; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; boron trichloride; In dichloromethane;
DOI:10.1021/jm061289j