2-(Chloroacetyl)-N-methyl-1,2-oxazinane-3-carboxamide

Base Information

Chemical Name:2-(Chloroacetyl)-N-methyl-1,2-oxazinane-3-carboxamide
CAS No.:70236-03-2
Molecular Formula:C₈H₁₃ClN₂O₃
Molecular Weight:220.656
Hs Code.:
DSSTox Substance ID:DTXSID30501439
Mol file:70236-03-2.mol

Synonyms:70236-03-2;2-(Chloroacetyl)-N-methyl-1,2-oxazinane-3-carboxamide;DTXSID30501439

Suppliers and Price of 2-(Chloroacetyl)-N-methyl-1,2-oxazinane-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-(Chloroacetyl)-N-methyl-1,2-oxazinane-3-carboxamide

Chemical Property:

PSA：62.13000
LogP:0.67200
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:220.0614700
Heavy Atom Count:14
Complexity:235

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC(=O)C1CCCON1C(=O)CCl

Technology Process of 2-(Chloroacetyl)-N-methyl-1,2-oxazinane-3-carboxamide

There total 4 articles about 2-(Chloroacetyl)-N-methyl-1,2-oxazinane-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70236-00-9
2-Chloracetyl-5,6-dihydro-N-methyl-1,2-oxazin-3-carboxamid

: 70236-03-2
DL-2-Chloroacetyl-tetrahydro-N-methyl-2H-1,2-oxazine-3-carboxamide

Guidance literature:: With hydrogen; Rh on carbon; In methanol; at 30 - 35 ℃; for 8h;
DOI:10.1021/jo01328a033

Reference yield:

: 18719-43-2
diethyl (3-chloropropyl)malonate

: 70236-03-2
DL-2-Chloroacetyl-tetrahydro-N-methyl-2H-1,2-oxazine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: EtONO, NaOEt / ethanol

2: ethanol / 6 h / 70 - 80 °C

3: diethyl ether / 25 °C

4: H₂ / Rh-C / methanol / 8 h / 30 - 35 °C

With ethyl nitrite; hydrogen; sodium ethanolate; Rh on carbon; In methanol; diethyl ether; ethanol;
DOI:10.1021/jo01328a033

Reference yield:

: 70235-99-3
5,6-Dihydro-N-methyl-4H-1,2-oxazin-3-carboxamid

: 70236-03-2
DL-2-Chloroacetyl-tetrahydro-N-methyl-2H-1,2-oxazine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 25 °C

2: H₂ / Rh-C / methanol / 8 h / 30 - 35 °C

With hydrogen; Rh on carbon; In methanol; diethyl ether;
DOI:10.1021/jo01328a033