2-(Chloroacetyl)-N-methyl-5,6-dihydro-2H-1,2-oxazine-3-carboxamide

Base Information

Chemical Name:2-(Chloroacetyl)-N-methyl-5,6-dihydro-2H-1,2-oxazine-3-carboxamide
CAS No.:70236-00-9
Molecular Formula:C₈H₁₁ClN₂O₃
Molecular Weight:218.64
Hs Code.:
DSSTox Substance ID:DTXSID70501438
Wikidata:Q82353799
Mol file:70236-00-9.mol

Synonyms:70236-00-9;DTXSID70501438;2-(Chloroacetyl)-N-methyl-5,6-dihydro-2H-1,2-oxazine-3-carboxamide

Suppliers and Price of 2-(Chloroacetyl)-N-methyl-5,6-dihydro-2H-1,2-oxazine-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-(Chloroacetyl)-N-methyl-5,6-dihydro-2H-1,2-oxazine-3-carboxamide

Chemical Property:

PSA：62.13000
LogP:0.79720
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:218.0458199
Heavy Atom Count:14
Complexity:278

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC(=O)C1=CCCON1C(=O)CCl

Technology Process of 2-(Chloroacetyl)-N-methyl-5,6-dihydro-2H-1,2-oxazine-3-carboxamide

There total 3 articles about 2-(Chloroacetyl)-N-methyl-5,6-dihydro-2H-1,2-oxazine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18719-43-2
diethyl (3-chloropropyl)malonate

: 70236-00-9
2-Chloracetyl-5,6-dihydro-N-methyl-1,2-oxazin-3-carboxamid

Guidance literature:: Multi-step reaction with 3 steps

1: EtONO, NaOEt / ethanol

2: ethanol / 6 h / 70 - 80 °C

3: diethyl ether / 25 °C

With ethyl nitrite; sodium ethanolate; In diethyl ether; ethanol;
DOI:10.1021/jo01328a033

Reference yield:

: 79-04-9
chloroacetyl chloride

: 70235-99-3
5,6-Dihydro-N-methyl-4H-1,2-oxazin-3-carboxamid

: 70236-00-9
2-Chloracetyl-5,6-dihydro-N-methyl-1,2-oxazin-3-carboxamid

Guidance literature:: In diethyl ether; at 25 ℃;
DOI:10.1021/jo01328a033

Reference yield:

: 70235-96-0
5,6-dihydro-4H-[1,2]oxazine-3-carboxylic acid ethyl ester

: 70236-00-9
2-Chloracetyl-5,6-dihydro-N-methyl-1,2-oxazin-3-carboxamid

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 6 h / 70 - 80 °C

2: diethyl ether / 25 °C

In diethyl ether; ethanol;
DOI:10.1021/jo01328a033