5-Bromo-N-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-4-(trifluoromethyl)thiazol-2-amine

Base Information

Chemical Name:5-Bromo-N-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-4-(trifluoromethyl)thiazol-2-amine
CAS No.:901309-22-6
Molecular Formula:C₁₉H₁₇BrF₃N₃OS
Molecular Weight:472.329
Hs Code.:

Synonyms:5-Bromo-N-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-4-(trifluoromethyl)thiazol-2-amine

Suppliers and Price of 5-Bromo-N-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-4-(trifluoromethyl)thiazol-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of 5-Bromo-N-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-4-(trifluoromethyl)thiazol-2-amine

Chemical Property:

Purity/Quality:: 95+% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Bromo-N-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-4-(trifluoromethyl)thiazol-2-amine

There total 13 articles about 5-Bromo-N-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-4-(trifluoromethyl)thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: N-{2-[2-(tert-butyl)phenoxy]-6-fluoropyridin-3-yl}-4-(trifluoromethyl)thiazol-2-amine

: 901309-22-6
5-bromo-N-{2-[2-(tert-butyl)phenoxy]pyridin-3-yl}-4-(trifluoromethyl)thiazol-2-amine

Guidance literature:: With N-Bromosuccinimide; In tetrahydrofuran; acetic acid; at 0 ℃; for 2h;
DOI:10.1016/j.ejmech.2019.01.006

Reference yield: 82.0%

: N-{2-[2-(tert-butyl)phenoxy]pyridin-3-yl}-4-(trifluoromethyl)thiazol-2-amine

: 901309-22-6
5-bromo-N-{2-[2-(tert-butyl)phenoxy]pyridin-3-yl}-4-(trifluoromethyl)thiazol-2-amine

Guidance literature:: With N-Bromosuccinimide; In tetrahydrofuran; acetic acid; at 0 ℃; for 2h;
DOI:10.1016/j.ejmech.2019.01.006

Reference yield:

: 88-18-6
2-tert-Butylphenol

: 901309-22-6
5-bromo-N-{2-[2-(tert-butyl)phenoxy]pyridin-3-yl}-4-(trifluoromethyl)thiazol-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 144 h / 130 °C

2: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran

3: dichloromethane / 2 h / 50 °C

4: lithium hydroxide / methanol; tetrahydrofuran / 2 h / 50 °C

5: 2,6-dimethylpyridine / ethanol / 90 °C

6: N-Bromosuccinimide; acetic acid / tetrahydrofuran / 20 °C

With 2,6-dimethylpyridine; N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.05.025